Pub. Date : 2000 Dec
PMID : 11082419
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Daunomycin is a potent inducer of p53 and NF-kappaB transcription factors. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | We demonstrated, in human breast and colon carcinoma cells, the binding of NF-kappaB dimers to the kappaB site and the transcriptional activation of the human p21 promoter by daunomycin and by NF-kappaB subunits, thereby confirming the functionality of this kappaB binding site. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. | Daunorubicin | nuclear factor kappa B subunit 1 | Homo sapiens |