PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11082419-1 2000 Daunomycin is a potent inducer of p53 and NF-kappaB transcription factors. Daunorubicin 0-10 nuclear factor kappa B subunit 1 Homo sapiens 42-51 11082419-4 2000 We demonstrated, in human breast and colon carcinoma cells, the binding of NF-kappaB dimers to the kappaB site and the transcriptional activation of the human p21 promoter by daunomycin and by NF-kappaB subunits, thereby confirming the functionality of this kappaB binding site. Daunorubicin 175-185 nuclear factor kappa B subunit 1 Homo sapiens 75-84 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 55-64 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 175-184 11082419-5 2000 However, using different tumor cell lines where p53 or NF-kappaB was inactive, we showed that p21 activation and cell cycle arrest induced by daunomycin was p53-dependent and NF-kappaB-independent, whereas daunomycin-induced apoptosis was p53- and NF-kappaB-independent. Daunorubicin 142-152 nuclear factor kappa B subunit 1 Homo sapiens 175-184