Pub. Date : 2000 Jun
PMID : 11031728
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our results indicate that mefloquine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner. | Mefloquine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 2 | Moreover, mefloquine reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay. | Mefloquine | ATP binding cassette subfamily B member 1 | Homo sapiens |
| 3 | Taken together, the results indicate that mefloquine reverses the multidrug-resistance phenotype through direct interaction with P-glycoprotein. | Mefloquine | ATP binding cassette subfamily B member 1 | Homo sapiens |