PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11031728-5 2000 Our results indicate that mefloquine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner. Mefloquine 26-36 ATP binding cassette subfamily B member 1 Homo sapiens 50-64 11031728-6 2000 Moreover, mefloquine reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay. Mefloquine 10-20 ATP binding cassette subfamily B member 1 Homo sapiens 66-80 11031728-7 2000 Taken together, the results indicate that mefloquine reverses the multidrug-resistance phenotype through direct interaction with P-glycoprotein. Mefloquine 42-52 ATP binding cassette subfamily B member 1 Homo sapiens 129-143