Pub. Date : 2000 Oct
PMID : 11006354
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The role of TNFalpha in regulating apoptotic signaling was investigated during subacute, low-dose (5.0 mg/kg) dimethylnitrosamine (DMN)-induced hepatotoxicity. | Dimethylnitrosamine | tumor necrosis factor | Mus musculus |
| 2 | In TNFalpha receptor (TNFR) intact (wild-type, WT) mice following 4 and 7 DMN exposures, hepatic transcripts for TNFalpha and TNFR-1 were elevated as compared to vehicle controls. | Dimethylnitrosamine | tumor necrosis factor | Mus musculus |
| 3 | Taken together, these data show DMN-induced hepatic TNFalpha expression and suggest that TNFR-1 signaling may be up regulated following 4 and 7 daily DMN exposures. | Dimethylnitrosamine | tumor necrosis factor | Mus musculus |