PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11006354-1 2000 The role of TNFalpha in regulating apoptotic signaling was investigated during subacute, low-dose (5.0 mg/kg) dimethylnitrosamine (DMN)-induced hepatotoxicity. Dimethylnitrosamine 110-129 tumor necrosis factor Mus musculus 12-20 11006354-2 2000 In TNFalpha receptor (TNFR) intact (wild-type, WT) mice following 4 and 7 DMN exposures, hepatic transcripts for TNFalpha and TNFR-1 were elevated as compared to vehicle controls. Dimethylnitrosamine 74-77 tumor necrosis factor Mus musculus 3-11 11006354-8 2000 Taken together, these data show DMN-induced hepatic TNFalpha expression and suggest that TNFR-1 signaling may be up regulated following 4 and 7 daily DMN exposures. Dimethylnitrosamine 32-35 tumor necrosis factor Mus musculus 52-60