Title : The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.

Pub. Date : 2000 Aug

PMID : 10971626






3 Functional Relationships(s)
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1 The releasing effect of gp120 was prevented by blocking the glycine site or the ion channel of NMDA receptors, but not the glutamate recognition site; in addition, the gp120 effect was strongly inhibited by nanomolar concentrations of Zn2+ ions and by low micromolar concentrations of ifenprodil. Glycine inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
2 The releasing effect of gp120 was prevented by blocking the glycine site or the ion channel of NMDA receptors, but not the glutamate recognition site; in addition, the gp120 effect was strongly inhibited by nanomolar concentrations of Zn2+ ions and by low micromolar concentrations of ifenprodil. Glycine inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens
3 It is concluded that gp120 acts as a very potent agonist at the glycine site of NMDA receptors sited on CCK- and SRIF-releasing nerve endings; the protein is able to activate the receptor channel in the absence of glutamate. Glycine inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens