Protein Name inter-alpha-trypsin inhibitor heavy chain 4
Organism Homo sapiens
Gene ID 3700
Gene Symbol

ITIH4

UniProt Q14624 (ITIH4_HUMAN), B7ZKJ8 (B7ZKJ8_HUMAN), B2RMS9 (B2RMS9_HUMAN)
Relationships Total Number of functionally related compound(s) : 788
Total Number of Articles : 1215
Description

inter-alpha-trypsin inhibitor heavy chain 4

Gene Summary

The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

synonyms
  • inter-alpha-trypsin inhibitor heavy chain H4
  • ITI heavy chain H4
  • inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)
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Properties