Title : Direct effects of propylthiouracil on testosterone secretion in rat testicular interstitial cells.

Pub. Date : 2000 Aug

PMID : 10928947






1 Functional Relationships(s)
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1 The results suggest that the inhibitory actions of PTU on testosterone secretion are exerted, at least in part, at the testicular level through a mechanism which is independent of thyroid status and which involves a reduction in P450scc activity and, hence, in the conversion of cholesterol to pregnenolone. Propylthiouracil cytochrome P450, family 11, subfamily a, polypeptide 1 Rattus norvegicus