Protein Name cytochrome P450, family 11, subfamily a, polypeptide 1
Organism Rattus norvegicus
Gene ID 29680
Gene Symbol

Cyp11a1

UniProt P14137 (CP11A_RAT)
Relationships Total Number of functionally related compound(s) : 208
Total Number of Articles : 341
Description

cytochrome P450, family 11, subfamily a, polypeptide 1

Gene Summary

Enables cholesterol binding activity and cholesterol monooxygenase (side-chain-cleaving) activity. Involved in several processes, including nervous system development; response to vitamin; and steroid biosynthetic process. Located in mitochondrial crista and perikaryon. Biomarker of several diseases, including glucose metabolism disease (multiple); hypertension; nephrosis; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia and congenital adrenal insufficiency. Orthologous to human CYP11A1 (cytochrome P450 family 11 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

synonyms
  • cholesterol side-chain cleavage enzyme, mitochondrial
  • cholesterol desmolase
  • cholesterol side-chain cleavage cytochrome P450
Click to show/hide the synonyms
Properties