Title : Cardiotrophin-1 increases angiotensinogen mRNA in rat cardiac myocytes through STAT3 : an autocrine loop for hypertrophy.

Pub. Date : 2000 Jun

PMID : 10856262






1 Functional Relationships(s)
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1 Cardiotrophin-1-induced STAT3 tyrosine phosphorylation and binding to the St-domain were suppressed by AG490, a specific JAK2 inhibitor, which also attenuated cardiotrophin-1-stimulated angiotensinogen promoter activity. Tyrosine Janus kinase 2 Rattus norvegicus