Pub. Date : 2000 Apr 28
PMID : 10777605
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The efficiency and fidelity of translesion synthesis past cisplatin and oxaliplatin GpG adducts by human DNA polymerase beta. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 2 | The data presented in this paper provide an analysis of translesion synthesis past cisplatin- and oxaliplatin-DNA adducts by pol beta functioning in both distributive and processive modes using primer extension and steady-state kinetic experiments. | Oxaliplatin | DNA polymerase beta | Homo sapiens |
| 3 | In the processive mode pol beta did not discriminate between cisplatin and oxaliplatin adducts, while in the distributive mode it displayed about 2-fold increased ability for translesion synthesis past oxaliplatin compared with cisplatin adducts. | Oxaliplatin | DNA polymerase beta | Homo sapiens |