Title : Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition.

Pub. Date : 2000 Apr 15

PMID : 10751437






2 Functional Relationships(s)
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1 Geranylgeranyl-pyrophosphate, an isoprenoid of mevalonate cascade, is a critical compound for rat primary cultured cortical neurons to protect the cell death induced by 3-hydroxy-3-methylglutaryl-CoA reductase inhibition. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus
2 We investigated the role of the intrinsic mevalonate cascade in the neuronal cell death (NCD) induced by the inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase in rat primary cortical neurons cultured from the brains of 17-d-old fetal SD rats. Mevalonic Acid 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus