Pub. Date : 2000 May
PMID : 10736562
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence. | Serine | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 2 | MARCKS (myristoylated alanine-rich C kinase substrate, 32 kDa) and its 20 kDa brother MARCKS-related protein (MRP) are abundant, widely distributed proteins unusually rich in alanine and glutamic acid, and with lysines, serines and phenylalanines concentrated in a compact "effector domain" (ED) near the middle of the sequence. | Serine | myristoylated alanine rich protein kinase C substrate | Homo sapiens |
| 3 | MARCKS (and MRP) interact inter alia with lipid bilayer membranes (via the myristoyl group and the ED), with protein kinases (which phosphorylate the serines in the ED), and with calmodulin (via the ED); synergies between these diverse interactions present an unusually rich array of possibilities for a variety of regulatory roles. | Serine | myristoylated alanine rich protein kinase C substrate | Homo sapiens |