Pub. Date : 2000 Feb 25
PMID : 10681520
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of Ras-GRF1 is critical for the induction of Rac-GEF activity as evidenced by inhibition by tyrosine kinase inhibitors. | Tyrosine | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 2 | Ras-GRF1 transiently expressed with v-Src was tyrosine-phosphorylated and showed significant GEF activity toward Rac, but not Rho and Cdc42, which was comparable with that induced by Gbetagamma. | Tyrosine | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 3 | Taken together, tyrosine phosphorylation by Src is sufficient for the induction of Rac-GEF activity of Ras-GRF1, which may imply the involvement of Src downstream of Gbetagamma to regulate Ras-GRF1. | Tyrosine | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |
| 4 | Taken together, tyrosine phosphorylation by Src is sufficient for the induction of Rac-GEF activity of Ras-GRF1, which may imply the involvement of Src downstream of Gbetagamma to regulate Ras-GRF1. | Tyrosine | Ras protein specific guanine nucleotide releasing factor 1 | Homo sapiens |