Title : Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.

Pub. Date : 2000 Jan 14

PMID : 10625675






1 Functional Relationships(s)
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Protein Name
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1 Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate. Amino Acids, Aromatic arachidonate 15-lipoxygenase Homo sapiens