PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10625675-10 2000 Enzymes that react with substrate "head first" (5-LOX and 8-LOX) have a bulky aromatic amino acid and a histidine in these positions, whereas lipoxygenases that accept substrates "tail first" (12-LOX and 15-LOX) have an aliphatic residue with a glutamine or aspartate. Amino Acids, Aromatic 78-97 arachidonate 15-lipoxygenase Homo sapiens 193-199