Pub. Date : 1999 Nov 15
PMID : 10597900
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The extent of CYP1A1 inhibition increases with time of preincubation at 37 degrees C, but not at 4 degrees C, in the presence of isoflavone plus NADPH; after 60 min preincubation the inhibition remains non-competitive, with apparent Ki values of 55 microM and 50 microM, respectively. | NADP | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required. | NADP | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |