PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10597900-8 1999 The extent of CYP1A1 inhibition increases with time of preincubation at 37 degrees C, but not at 4 degrees C, in the presence of isoflavone plus NADPH; after 60 min preincubation the inhibition remains non-competitive, with apparent Ki values of 55 microM and 50 microM, respectively. NADP 145-150 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 14-20 10597900-11 1999 The dependency on NADPH, temperature and time for inhibition of CYP1A1 suggests that metabolism of either isoflavone or molecular oxygen to reactive species is required. NADP 18-23 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 64-70