Pub. Date : 1999 Dec
PMID : 10565852
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | 4-methylcatechol increases brain-derived neurotrophic factor content and mRNA expression in cultured brain cells and in rat brain in vivo. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 2 | In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 3 | In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 4 | 4-MC elevated BDNF content in culture media of both rat astrocytes and neurons with different dose-response relations. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 5 | The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 6 | The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 7 | The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 8 | First, we found that ventricularly administered 4-MC facilitated an increase in the BDNF content in the cerebral cortex and hippocampus in association with its diffusion into the brain parenchyma. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |
| 9 | These results demonstrate that 4-MC, once delivered into the brain, can stimulate BDNF synthesis. | 4-methylcatechol | brain-derived neurotrophic factor | Rattus norvegicus |