PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10565852-0	1999	4-methylcatechol increases brain-derived neurotrophic factor content and mRNA expression in cultured brain cells and in rat brain in vivo.	4-methylcatechol	0-16	brain-derived neurotrophic factor	Rattus norvegicus	27-60	
10565852-2	1999	In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain.	4-methylcatechol	53-69	brain-derived neurotrophic factor	Rattus norvegicus	182-186	
10565852-2	1999	In the present study, we investigated the effects of 4-methylcatechol (4-MC), which stimulates nerve growth factor synthesis and protects against peripheral neuropathies in rats, on BDNF content and mRNA expression in cultured brain cells and in vivo in the rat brain.	4-methylcatechol	71-75	brain-derived neurotrophic factor	Rattus norvegicus	182-186	
10565852-3	1999	4-MC elevated BDNF content in culture media of both rat astrocytes and neurons with different dose-response relations.	4-methylcatechol	0-4	brain-derived neurotrophic factor	Rattus norvegicus	14-18	
10565852-4	1999	The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes.	4-methylcatechol	101-105	brain-derived neurotrophic factor	Rattus norvegicus	16-20	
10565852-4	1999	The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes.	4-methylcatechol	101-105	brain-derived neurotrophic factor	Rattus norvegicus	68-72	
10565852-4	1999	The increase in BDNF mRNA level was correlated with the increase in BDNF content, demonstrating that 4-MC can stimulate BDNF synthesis of both neurons and astrocytes.	4-methylcatechol	101-105	brain-derived neurotrophic factor	Rattus norvegicus	68-72	
10565852-6	1999	First, we found that ventricularly administered 4-MC facilitated an increase in the BDNF content in the cerebral cortex and hippocampus in association with its diffusion into the brain parenchyma.	4-methylcatechol	48-52	brain-derived neurotrophic factor	Rattus norvegicus	84-88	
10565852-9	1999	These results demonstrate that 4-MC, once delivered into the brain, can stimulate BDNF synthesis.	4-methylcatechol	31-35	brain-derived neurotrophic factor	Rattus norvegicus	82-86