Title : Down-regulation of cyclin D1 by transcriptional repression in MCF-7 human breast carcinoma cells induced by flavopiridol.

Pub. Date : 1999 Sep 15

PMID : 10493518






2 Functional Relationships(s)
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1 Flavopiridol is a novel flavonoid that induces cell cycle arrest at different stages of the cell cycle because of the inhibition of cyclin-dependent kinases (cdks). alvocidib cyclin dependent kinase 2 Homo sapiens
2 A. Carlson et al., Cancer Res., 56: 2973-2978, 1996), we observed that exposure of the MCF-7 breast carcinoma cell line to flavopiridol resulted in G1-S arrest, which was associated with the loss of cdk4 and cdk2 activity by 24 h of exposure. alvocidib cyclin dependent kinase 2 Homo sapiens