PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10385692-1	1999	The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis.	Cyclic GMP	4-8	phosphodiesterase 5A	Homo sapiens	50-54	
10385692-1	1999	The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis.	Cyclic GMP	17-21	phosphodiesterase 5A	Homo sapiens	50-54	
10385692-1	1999	The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis.	Cyclic GMP	17-21	phosphodiesterase 5A	Homo sapiens	50-54	
10385692-1	1999	The cGMP-binding cGMP-specific phosphodiesterase (PDE5) degrades cGMP and regulates the intracellular level of cGMP in many tissues, including the smooth muscle of the corpus cavernosum of the penis.	Cyclic GMP	17-21	phosphodiesterase 5A	Homo sapiens	50-54	
10385692-2	1999	Sildenafil (Viagra), a specific PDE5 inhibitor, promotes penile erection by blocking the activity of PDE5, which causes cGMP to accumulate in the corpus cavernosum.	Cyclic GMP	120-124	phosphodiesterase 5A	Homo sapiens	101-105	
10385692-3	1999	In the present study, sildenafil, like other PDE5 inhibitors, stimulates cGMP binding to the allosteric sites of PDE5 by interacting at the catalytic site of this enzyme, but the drug does not compete with cGMP for binding at the allosteric sites.	Cyclic GMP	73-77	phosphodiesterase 5A	Homo sapiens	113-117	
10385692-8	1999	The affinity of each of these inhibitors for PDE5 is much higher than that of cGMP itself (Km = 2000 nM).	Cyclic GMP	78-82	phosphodiesterase 5A	Homo sapiens	45-49