Title : Inhibitory effects of combinations of HER-2/neu antibody and chemotherapeutic agents used for treatment of human breast cancers.

Pub. Date : 1999 Apr 1

PMID : 10327070






2 Functional Relationships(s)
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1 Previous studies have demonstrated a synergistic interaction between rhuMAb HER2 and the cytotoxic drug cisplatin in human breast and ovarian cancer cells. Cisplatin erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 Synergistic interactions at clinically relevant drug concentrations were observed for rhuMAb HER2 in combination with cisplatin (CI=0.48, P=0.003), thiotepa (CI=0.67, P=0.0008), and etoposide (CI=0.54, P=0.0003). Cisplatin erb-b2 receptor tyrosine kinase 2 Homo sapiens