Title : Methadone N-demethylation in human liver microsomes: lack of stereoselectivity and involvement of CYP3A4.

Pub. Date : 1999 Apr

PMID : 10233205






1 Functional Relationships(s)
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1 CONCLUSIONS: The N-demethylation of methadone in human liver microsomes is not markedly stereoselective, and is mediated mainly by CYP3A4 with the possible involvement of CYP2C9 and CYP2C19. Methadone cytochrome P450 family 2 subfamily C member 19 Homo sapiens