Pub. Date : 1999 Feb
PMID : 10202848
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of angiotensin (Ang) II type 1 (AT1) receptors in various target tissues of adult Sprague-Dawley rats was studied after single oral administration of TCV-116. | candesartan cilexetil | angiotensin II receptor, type 1a | Rattus norvegicus |
| 2 | Four hours after the administration of TCV-116 (1 mg/kg), Ang II-receptor binding was markedly inhibited in the kidney (20% of control), adrenal cortex (27%), thoracic aorta (57%), heart (55%) and testis (76%) where AT1 receptors predominate. | candesartan cilexetil | angiotensin II receptor, type 1a | Rattus norvegicus |
| 3 | These data indicate that orally administered TCV-116 specifically binds to AT1 receptors both in peripheral tissues and the central nervous system. | candesartan cilexetil | angiotensin II receptor, type 1a | Rattus norvegicus |