Title : Peripheral blood mononuclear cells isolated from patients with diabetic nephropathy show increased activation of the oxidative-stress sensitive transcription factor NF-kappaB.

Pub. Date : 1999 Feb

PMID : 10064103






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (alpha-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48% and NF-kappaB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38%. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens
2 In a 3 day intervention study in which 600 mg of the antioxidant thioctic acid (alpha-lipoic acid) per day were given to nine patients with diabetic nephropathy oxidative stress in plasma samples was decreased by 48% and NF-kappaB binding activity in ex vivo isolated peripheral blood mononuclear cells by 38%. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens
3 NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens
4 NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens
5 NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens
6 NF-kappaB activation is at least in part dependent on oxidative stress since thioctic acid (alpha-lipoic acid) reduced NF-kappaB binding activity. Thioctic Acid nuclear factor kappa B subunit 1 Homo sapiens