| 1 |
33398415 | The influence of the long-term chemical activation of the nuclear receptor pregnane X receptor (PXR) on liver carcinogenesis in mice. | 2021 Mar |
2 |
| 2 |
34312179 | Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice. | 2021 Oct |
2 |
| 3 |
34629731 | Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). | 2021 Oct |
4 |
| 4 |
34880749 | Regulation of Cytochrome P450 2a5 by Artemisia capillaris and 6,7-Dimethylesculetin in Mouse Hepatocytes. | 2021 |
2 |
| 5 |
31836555 | Analysis of β-catenin gene mutations and gene expression in liver tumours of C57BL/10J mice produced by chronic administration of sodium phenobarbital. | 2020 Jan 30 |
2 |
| 6 |
32193417 | Nuclear receptor CAR-ERα signaling regulates the estrogen sulfotransferase gene in the liver. | 2020 Mar 19 |
2 |
| 7 |
32735318 | Comparison of the Hepatic Effects of Phenobarbital in Chimeric Mice Containing Either Rat or Human Hepatocytes With Humanized Constitutive Androstane Receptor and Pregnane X Receptor Mice. | 2020 Oct 1 |
1 |
| 8 |
32892155 | Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels. | 2020 Nov |
1 |
| 9 |
31170421 | Stilbene compound trans-3,4,5,4´-tetramethoxystilbene, a potential anticancer drug, regulates constitutive androstane receptor (Car) target genes, but does not possess proliferative activity in mouse liver. | 2019 Oct 1 |
1 |
| 10 |
31436536 | Mechanistic Insights of Phenobarbital-Mediated Activation of Human but Not Mouse Pregnane X Receptor. | 2019 Sep |
1 |
| 11 |
29269410 | Epidermal Growth Factor Represses Constitutive Androstane Receptor Expression in Primary Human Hepatocytes and Favors Regulation by Pregnane X Receptor. | 2018 Mar |
2 |
| 12 |
29425889 | Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes. | 2018 Mar 1 |
6 |
| 13 |
29716964 | Nuclear Receptor CAR Suppresses GADD45B-p38 MAPK Signaling to Promote Phenobarbital-induced Proliferation in Mouse Liver. | 2018 Aug |
4 |
| 14 |
30090615 | Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators. | 2018 Jul 1 |
3 |
| 15 |
30115646 | Mouse Hepatomas with Ha-ras and B-raf Mutations Differ in Mitogen-Activated Protein Kinase Signaling and Response to Constitutive Androstane Receptor Activation. | 2018 Nov |
2 |
| 16 |
28058446 | Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. | 2017 Aug |
1 |
| 17 |
28218408 | Toxaphene-induced mouse liver tumorigenesis is mediated by the constitutive androstane receptor. | 2017 Aug |
4 |
| 18 |
28265001 | Phosphorylated Nuclear Receptor CAR Forms a Homodimer To Repress Its Constitutive Activity for Ligand Activation. | 2017 May 15 |
1 |
| 19 |
28541575 | Xenobiotic CAR Activators Induce Dlk1-Dio3 Locus Noncoding RNA Expression in Mouse Liver. | 2017 Aug 1 |
4 |
| 20 |
28546505 | Role of CYP2B in Phenobarbital-Induced Hepatocyte Proliferation in Mice. | 2017 Aug |
6 |
| 21 |
28580885 | β-catenin Mutations Are Not Involved in Early-stage Hepatocarcinogenesis Induced by Protoporphyrinogen Oxidase Inhibitors in Mice. | 2017 Jun |
1 |
| 22 |
30090543 | Candidate genes responsible for early key events of phenobarbital-promoted mouse hepatocellular tumorigenesis based on differentiation of regulating genes between wild type mice and humanized chimeric mice. | 2017 Nov 1 |
2 |
| 23 |
26994072 | Phenobarbital and Insulin Reciprocate Activation of the Nuclear Receptor Constitutive Androstane Receptor through the Insulin Receptor. | 2016 May |
1 |
| 24 |
27664318 | Methyl isobutyl ketone-induced hepatocellular carcinogenesis in B6C3F1 mice: A constitutive androstane receptor (CAR)-mediated mode of action. | 2016 Nov |
1 |
| 25 |
27693619 | Inhibition of β-catenin signaling by phenobarbital in hepatoma cells in vitro. | 2016 Aug 31 |
5 |
| 26 |
25949234 | Identification of chemical modulators of the constitutive activated receptor (CAR) in a gene expression compendium. | 2015 |
1 |
| 27 |
26171734 | Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver. | 2015 Oct 1 |
2 |
| 28 |
24180433 | Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator. | 2014 Jan |
2 |
| 29 |
24449422 | Dose-response modeling of early molecular and cellular key events in the CAR-mediated hepatocarcinogenesis pathway. | 2014 Apr |
4 |
| 30 |
24464994 | Computational modeling identifies key gene regulatory interactions underlying phenobarbital-mediated tumor promotion. | 2014 Apr |
1 |
| 31 |
24675475 | Phenobarbital and propiconazole toxicogenomic profiles in mice show major similarities consistent with the key role that constitutive androstane receptor (CAR) activation plays in their mode of action. | 2014 Jul 3 |
3 |
| 32 |
24690595 | Phenobarbital induces cell cycle transcriptional responses in mouse liver humanized for constitutive androstane and pregnane x receptors. | 2014 Jun |
4 |
| 33 |
24863967 | Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR. | 2014 Aug 1 |
5 |
| 34 |
25052003 | Clofibric acid induces hepatic CYP 2B1/2 via constitutive androstane receptor not via peroxisome proliferator activated receptor alpha in rat. | 2014 |
4 |
| 35 |
25145657 | Human hepatocytes support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogen sodium phenobarbital in an in vivo study using a chimeric mouse with humanized liver. | 2014 Nov |
3 |
| 36 |
25542016 | The roles of co-chaperone CCRP/DNAJC7 in Cyp2b10 gene activation and steatosis development in mouse livers. | 2014 |
2 |
| 37 |
23291559 | Nuclear receptor CAR specifically activates the two-pore K+ channel Kcnk1 gene in male mouse livers, which attenuates phenobarbital-induced hepatic hyperplasia. | 2013 Mar |
2 |
| 38 |
23528251 | Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression. | 2013 May 23 |
3 |
| 39 |
23531792 | Different pathways of constitutive androstane receptor-mediated liver hypertrophy and hepatocarcinogenesis in mice treated with piperonyl butoxide or decabromodiphenyl ether. | 2013 |
4 |
| 40 |
21424122 | Nuclear receptor CAR-regulated expression of the FAM84A gene during the development of mouse liver tumors. | 2011 Jun |
3 |
| 41 |
21455306 | Phenobarbital mediates an epigenetic switch at the constitutive androstane receptor (CAR) target gene Cyp2b10 in the liver of B6C3F1 mice. | 2011 Mar 24 |
5 |
| 42 |
19850644 | Characterization of peroxisome proliferator-activated receptor alpha--independent effects of PPARalpha activators in the rodent liver: di-(2-ethylhexyl) phthalate also activates the constitutive-activated receptor. | 2010 Jan |
4 |
| 43 |
20185760 | Hepatic expression of thyroid hormone-responsive spot 14 protein is regulated by constitutive androstane receptor (NR1I3). | 2010 Apr |
1 |
| 44 |
20371638 | The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. | 2010 Jul |
3 |
| 45 |
20404936 | Nuclear receptor CAR represses TNFalpha-induced cell death by interacting with the anti-apoptotic GADD45B. | 2010 Apr 12 |
9 |
| 46 |
20816995 | The increased CAR-dependent metabolism of thyroid hormones in mice with high cancer susceptibility. | 2010 Sep 25 |
4 |
| 47 |
19047470 | Dexamethasone induction of murine CYP2B genes requires the glucocorticoid receptor. | 2009 Mar |
1 |
| 48 |
19136022 | Time-course comparison of xenobiotic activators of CAR and PPARalpha in mouse liver. | 2009 Mar 1 |
1 |
| 49 |
19196849 | Constitutive androstane receptor-mediated changes in bile acid composition contributes to hepatoprotection from lithocholic acid-induced liver injury in mice. | 2009 May |
3 |
| 50 |
19233941 | Multiple genes exhibit phenobarbital-induced constitutive active/androstane receptor-mediated DNA methylation changes during liver tumorigenesis and in liver tumors. | 2009 Apr |
8 |