Title : Antiepileptic Drug-Activated Constitutive Androstane Receptor Inhibits Peroxisome Proliferator-Activated Receptor α and Peroxisome Proliferator-Activated Receptor γ Coactivator 1α-Dependent Gene Expression to Increase Blood Triglyceride Levels.

Pub. Date : 2020 Nov

PMID : 32892155






1 Functional Relationships(s)
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1 Treatment of mice with the CAR activator phenobarbital, an antiepileptic drug, increased plasma triglyceride levels and decreased the hepatic expression of PPARalpha target genes related to lipid metabolism. Phenobarbital nuclear receptor subfamily 1, group I, member 3 Mus musculus