| 51 |
19689280 | Structure-activity relationships of low molecular weight heparins expose to the risk of achieving inappropriate targets in patients with renal failure. | 2009 |
2 |
| 52 |
18062909 | Thrombin-induced IL-6 production in human synovial fibroblasts is mediated by PAR1, phospholipase C, protein kinase C alpha, c-Src, NF-kappa B and p300 pathway. | 2008 Mar |
1 |
| 53 |
18585267 | Tryptophan-contained peptide-functional nanomaterials as general spectrofluorometric reagents for enzyme. | 2008 Jun 30 |
3 |
| 54 |
18761726 | The PKB inhibitor Akti-1/2 potentiates PAR-1-mediated platelet function independently of its ability to block PKB. | 2008 Nov |
1 |
| 55 |
17311912 | Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. | 2007 Apr 13 |
1 |
| 56 |
17428793 | Structural basis of Na+ activation mimicry in murine thrombin. | 2007 Jun 1 |
1 |
| 57 |
17888529 | A more serine way to die: defining the characteristics of serine protease-mediated cell death cascades. | 2007 Oct |
1 |
| 58 |
16410745 | Thrombin and prothrombin are expressed by neurons and glial cells and accumulate in neurofibrillary tangles in Alzheimer disease brain. | 2006 Jan |
2 |
| 59 |
15522964 | Thrombin induces endocytosis of endoglin and type-II TGF-beta receptor and down-regulation of TGF-beta signaling in endothelial cells. | 2005 Mar 1 |
1 |
| 60 |
15746105 | Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain. | 2005 May 6 |
3 |
| 61 |
15899702 | Proteolytic susceptibility of the serine protease inhibitor trappin-2 (pre-elafin): evidence for tryptase-mediated generation of elafin. | 2005 Apr |
1 |
| 62 |
16126727 | Endothelial thrombomodulin induces Ca2+ signals and nitric oxide synthesis through epidermal growth factor receptor kinase and calmodulin kinase II. | 2005 Oct 28 |
2 |
| 63 |
14679197 | Residue Asp-189 controls both substrate binding and the monovalent cation specificity of thrombin. | 2004 Mar 12 |
1 |
| 64 |
14978285 | Crystal structure of the complex between thrombin and the central "E" region of fibrin. | 2004 Mar 2 |
2 |
| 65 |
15137766 | Proton inventory studies of alpha-thrombin-catalyzed reactions of substrates with selected P and P' sites. | 2004 May 19 |
3 |
| 66 |
15183043 | A critical role for thrombin in platelet aggregation under high shear stress. | 2004 |
1 |
| 67 |
15223139 | Temperature dependence of the thrombin-catalyzed proteolysis of prothrombin. | 2004 Jul 1 |
1 |
| 68 |
15534036 | Protease-activated receptors in neuronal development, neurodegeneration, and neuroprotection: thrombin as signaling molecule in the brain. | 2004 Dec |
1 |
| 69 |
12603843 | Thrombin induces in vivo degeneration of nigral dopaminergic neurones along with the activation of microglia. | 2003 Mar |
1 |
| 70 |
12871328 | Factor Xa is highly protected from antithrombin-fondaparinux and antithrombin-enoxaparin when incorporated into the prothrombinase complex. | 2003 Jun |
1 |
| 71 |
12926277 | Synthesis and hydrolysis studies of a peptide containing the reactive triad of serine proteases with an associated linker to a dye on a solid phase support. | 2003 May 7 |
1 |
| 72 |
12930825 | Phosphorylation of SNAP-23 in activated human platelets. | 2003 Nov 7 |
1 |
| 73 |
14550568 | Regulation of glycogen synthase kinase 3 in human platelets: a possible role in platelet function? | 2003 Oct 9 |
1 |
| 74 |
11851400 | Characterization of the residues involved in the human alpha-thrombin-haemadin complex: an exosite II-binding inhibitor. | 2002 Feb 26 |
1 |
| 75 |
12181318 | Ser(214) is crucial for substrate binding to serine proteases. | 2002 Oct 25 |
1 |
| 76 |
12441908 | Two antiprothrombin antibodies against prothrombin and prothrombin-phosphatidyl serine show partial but not total identity. | 2002 Dec |
1 |
| 77 |
11278943 | The use of prothrombin(S525C) labeled with fluorescein to directly study the inhibition of prothrombinase by antithrombin during prothrombin activation. | 2001 May 25 |
1 |
| 78 |
11389017 | Autoantibody against prothrombin aberrantly alters the proenzyme to facilitate formation of a complex with its physiological inhibitor antithrombin III without thrombin conversion. | 2001 Jun 15 |
1 |
| 79 |
10828960 | Monoclonal antibody light chain with prothrombinase activity. | 2000 May 30 |
2 |
| 80 |
10831589 | Factor VIII C2 domain contains the thrombin-binding site responsible for thrombin-catalyzed cleavage at Arg1689. | 2000 Aug 18 |
2 |
| 81 |
10978317 | Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. | 2000 Dec 1 |
2 |
| 82 |
11027562 | Junctional adhesion molecule (JAM) is phosphorylated by protein kinase C upon platelet activation. | 2000 Oct 5 |
1 |
| 83 |
10024525 | Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli. | 1999 Mar 1 |
1 |
| 84 |
10051558 | Unexpected crucial role of residue 225 in serine proteases. | 1999 Mar 2 |
1 |
| 85 |
10080949 | alpha-thrombin inhibits interleukin-6-induced Stat3 signaling and gp130 gene expression in primary cultures of human lung fibroblasts. | 1999 Mar 24 |
1 |
| 86 |
10413505 | Shutoff and agonist-triggered internalization of protease-activated receptor 1 can be separated by mutation of putative phosphorylation sites in the cytoplasmic tail. | 1999 Jul 20 |
3 |
| 87 |
10457985 | [Natural and synthetic inhibitors of thrombin. II. Synthetic low-molecular-weight inhibitors]. | 1999 Jan-Feb |
3 |
| 88 |
10465405 | Design, synthesis and biological evaluation of selective boron-containing thrombin inhibitors. | 1999 Jul |
2 |
| 89 |
10552952 | Lupus anticoagulants form immune complexes with prothrombin and phospholipid that can augment thrombin production in flow. | 1999 Nov 15 |
1 |
| 90 |
9468497 | Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. | 1998 Feb 20 |
4 |
| 91 |
9588188 | Thrombin per se does not induce tyrosine protein phosphorylation in human platelets as judged by western blotting, while collagen does: the significance of synergistic, autocrine stimulation. | 1998 Apr 28 |
1 |
| 92 |
9783670 | Translocation and phosphorylation of cytosolic phospholipase A2 in activated platelets. | 1998 Oct 1 |
1 |
| 93 |
10089499 | Biochemical and crystallographic characterization of homologous non-peptidic thrombin inhibitors having alternate binding modes. | 1998 Nov 1 |
1 |
| 94 |
8999861 | Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I. | 1997 Jan 17 |
1 |
| 95 |
9031466 | Protein tyrosine phosphatase SHP-1 fails to associate with cytoskeleton but is normally phosphorylated upon thrombin stimulation of thrombasthenic platelets. | 1997 Jan |
1 |
| 96 |
9033392 | Contribution of lysine 60f to S1' specificity of thrombin. | 1997 Feb 4 |
2 |
| 97 |
9198185 | Thrombomodulin structure and function. | 1997 Jul |
1 |
| 98 |
9313859 | Modulation of human alpha-thrombin activity with phosphonate ester inhibitors. | 1997 Aug |
1 |
| 99 |
9359863 | Thrombin produces phosphorylation of cytosolic phospholipase A2 by a mitogen-activated protein kinase kinase-independent mechanism in the human astrocytoma cell line 1321N1. | 1997 Nov 15 |
1 |
| 100 |
9374664 | Site-specific thrombin receptor antibodies inhibit Ca2+ signaling and increased endothelial permeability. | 1997 Nov |
2 |