| 1 |
33137426 | Repeat-dose animal toxicity studies and genotoxicity study with deactivated alkaline serine protease (DASP), a protein low in phenylalanine (PHE). | 2020 Dec |
2 |
| 2 |
19484400 | Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity. | 2010 Apr |
1 |
| 3 |
19299505 | Structure of granzyme C reveals an unusual mechanism of protease autoinhibition. | 2009 Apr 7 |
1 |
| 4 |
19715676 | Role of P2 glycine in determining the specificity of antithrombin reaction with coagulation proteases. | 2009 Nov 6 |
2 |
| 5 |
17613990 | Ultrastructural changes to rabbit fibrin and platelets due to aspartame. | 2007 Mar-Apr |
1 |
| 6 |
16839343 | Proteolytic cleavage of factor VIII heavy chain is required to expose the binding-site for low-density lipoprotein receptor-related protein within the A2 domain. | 2006 Jul |
1 |
| 7 |
17074754 | Rapid kinetics of Na+ binding to thrombin. | 2006 Dec 29 |
1 |
| 8 |
16566136 | [Interrelation between thrombin structure and its stability]. | 2005 May-Jun |
1 |
| 9 |
14978285 | Crystal structure of the complex between thrombin and the central "E" region of fibrin. | 2004 Mar 2 |
1 |
| 10 |
15137766 | Proton inventory studies of alpha-thrombin-catalyzed reactions of substrates with selected P and P' sites. | 2004 May 19 |
1 |
| 11 |
15189031 | Design and synthesis of novel biologically active thrombin receptor non-peptide mimetics based on the pharmacophoric cluster Phe/Arg/NH2 of the Ser42-Phe-Leu-Leu-Arg46 motif sequence: platelet aggregation and relaxant activities. | 2004 Jun 17 |
5 |
| 12 |
14531686 | Probing the kinetic landscape of transient peptide-protein interactions by use of peptide (15)n NMR relaxation dispersion spectroscopy: binding of an antithrombin peptide to human prothrombin. | 2003 Oct 15 |
3 |
| 13 |
11460501 | Mutation of W215 compromises thrombin cleavage of fibrinogen, but not of PAR1 or protein C. | 2001 |
1 |
| 14 |
10831587 | Fluorescence properties and functional roles of tryptophan residues 60d, 96, 148, 207, and 215 of thrombin. | 2000 Sep 22 |
1 |
| 15 |
10920258 | Edge-to-face CH/pi interaction between ligand Phe-phenyl and receptor aromatic group in the thrombin receptor activation. | 2000 Aug |
1 |
| 16 |
11020444 | Inhibition of cellular action of thrombin by N3-cyclopropyl-7-[[4-(1-methylethyl)phenyl]methyl]-7H-pyrrolo[3, 2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. | 2000 Nov 15 |
1 |
| 17 |
11087398 | Role of residue Phe225 in the cofactor-mediated, allosteric regulation of the serine protease coagulation factor VIIa. | 2000 Nov 28 |
1 |
| 18 |
10051558 | Unexpected crucial role of residue 225 in serine proteases. | 1999 Mar 2 |
1 |
| 19 |
9753458 | Substitution of tyrosine for phenylalanine in fibrinopeptide A results in preferential thrombin cleavage of fibrinopeptide B from fibrinogen. | 1998 Sep 29 |
3 |
| 20 |
9325262 | Evidence for allosteric linkage between exosites 1 and 2 of thrombin. | 1997 Oct 10 |
1 |
| 21 |
9398287 | Ionic properties of membrane association by vitamin K-dependent proteins: the case for univalency. | 1997 Dec 16 |
1 |
| 22 |
8615773 | Thrombin stimulates wortmannin-inhibitable phosphoinositide 3-kinase and membrane blebbing in CHRF-288 cells. | 1996 Mar 15 |
2 |
| 23 |
8745396 | Structural resiliency of an EGF-like subdomain bound to its target protein, thrombin. | 1996 Feb |
1 |
| 24 |
8855937 | Nonpolar interactions of thrombin and its inhibitors at the fibrinogen recognition exosite: thermodynamic analysis. | 1996 Oct 8 |
2 |
| 25 |
7563081 | Thrombin-bound structures of designed analogs of human fibrinopeptide A determined by quantitative transferred NOE spectroscopy: a new structural basis for thrombin specificity. | 1995 Oct 6 |
1 |
| 26 |
7582983 | Peptide-derived transition state analogue inhibitors of thrombin; synthesis, activity and selectivity. | 1995 Aug |
1 |
| 27 |
7721887 | Identification of three tyrosine residues of glycoprotein Ib alpha with distinct roles in von Willebrand factor and alpha-thrombin binding. | 1995 Apr 21 |
1 |
| 28 |
7739010 | Characterization of a class of peptide boronates with neutral P1 side chains as highly selective inhibitors of thrombin. | 1995 Apr 28 |
1 |
| 29 |
7802348 | [Cellular receptor of thrombin]. | 1994 |
1 |
| 30 |
7948726 | Thrombin-bound conformation of a cyclic anticoagulant peptide using transferred nuclear Overhauser effect (NOE), distance geometry, and NOE simulations. | 1994 Sep |
1 |
| 31 |
8074680 | Differential roles of two consecutive phenylalanine residues in thrombin receptor-tethered ligand peptides (SFFLRNP) in thrombin receptor activation. | 1994 Aug 30 |
2 |
| 32 |
8381415 | Alanine-scanning mutagenesis of the epidermal growth factor-like domains of human thrombomodulin identifies critical residues for its cofactor activity. | 1993 Feb 5 |
2 |
| 33 |
8426361 | Highly selective tripeptide thrombin inhibitors. | 1993 Feb 5 |
1 |
| 34 |
1290488 | Thrombin-specific inhibition by and slow cleavage of hirulog-1. | 1992 May 1 |
1 |
| 35 |
1434539 | Thrombin enhancement of interleukin-1 and tumor necrosis factor-alpha induced polymorphonuclear leukocyte migration. | 1992 Nov |
2 |
| 36 |
1547237 | Conformational stability of a thrombin-binding peptide derived from the hirudin C-terminus. | 1992 Mar 10 |
1 |
| 37 |
1590777 | Inhibition of the amplification reactions of blood coagulation by site-specific inhibitors of alpha-thrombin. | 1992 May 1 |
1 |
| 38 |
2059196 | Hirulog peptides with scissile bond replacements resistant to thrombin cleavage. | 1991 Jun 28 |
1 |
| 39 |
2369894 | Recombinant human protein C derivatives: altered response to calcium resulting in enhanced activation by thrombin. | 1990 Aug |
1 |
| 40 |
2380171 | The COOH-terminal domain of hirudin. An exosite-directed competitive inhibitor of the action of alpha-thrombin on fibrinogen. | 1990 Aug 15 |
1 |
| 41 |
2480947 | Permeability of human endothelial monolayers: effect of vasoactive agonists and cAMP. | 1989 Nov |
1 |
| 42 |
2742826 | High-resolution NMR studies of fibrinogen-like peptides in solution: interaction of thrombin with residues 1-23 of the A alpha chain of human fibrinogen. | 1989 Apr 4 |
2 |
| 43 |
2742827 | High-resolution NMR studies of fibrinogen-like peptides in solution: structure of a thrombin-bound peptide corresponding to residues 7-16 of the A alpha chain of human fibrinogen. | 1989 Apr 4 |
1 |
| 44 |
2742828 | High-resolution NMR studies of fibrinogen-like peptides in solution: structural basis for the bleeding disorder caused by a single mutation of Gly(12) to Val(12) in the A alpha chain of human fibrinogen Rouen. | 1989 Apr 4 |
1 |
| 45 |
3166991 | High-resolution NMR studies of fibrinogen-like peptides in solution: resonance assignments and conformational analysis of residues 1-23 of the A alpha chain of human fibrinogen. | 1988 Jun 14 |
1 |
| 46 |
3771562 | Molecular defect of prothrombin Barcelona. Substitution of cysteine for arginine at residue 273. | 1986 Nov 15 |
2 |
| 47 |
7150549 | Mechanism of action of thrombin on fibrinogen. Direct evidence for the involvement of phenylalanine at position P9. | 1982 Nov 23 |
3 |