N-(3-propylcarbamoyloxirane-2-carbonyl)-isoleucyl-proline

cathepsin B ; Homo sapiens







48 Article(s)
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1 34994563 Inhibition of Cathepsin B and SAPC Secreted by HIV-Infected Macrophages Reverses Common and Unique Apoptosis Pathways. 2022 Feb 4 1
2 35119840 Molecular Features of CA-074 pH-Dependent Inhibition of Cathepsin B. 2022 Feb 15 2
3 35156579 Cathepsin B - A Neuronal Death Mediator in Alzheimer's Disease Leads to Neurodegeneration. 2022 Feb 14 1
4 33510618 The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes. 2020 1
5 29432801 Leptospira interrogans infection leads to IL-1β and IL-18 secretion from a human macrophage cell line through reactive oxygen species and cathepsin B mediated-NLRP3 inflammasome activation. 2018 Apr 1
6 29454581 Emerging roles of microglial cathepsins in neurodegenerative disease. 2018 May 1
7 29531800 IRE1α deficiency promotes tumor cell death and eIF2α degradation through PERK dipendent autophagy. 2018 Dec 1
8 30591146 Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells. 2018 Nov 1
9 29086922 Myoepithelial cell-specific expression of stefin A as a suppressor of early breast cancer invasion. 2017 Dec 1
10 25808857 Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis. 2016 May 2
11 26092112 HIV-infected microglia mediate cathepsin B-induced neurotoxicity. 2015 Oct 1
12 25209871 Cocaine potentiates cathepsin B secretion and neuronal apoptosis from HIV-infected macrophages. 2014 Dec 1
13 25260629 Cathepsin B contributes to Na+ hyperabsorption in cystic fibrosis airway epithelial cultures. 2014 Dec 1 3
14 22266111 Cathepsin B inhibition limits bone metastasis in breast cancer. 2012 Mar 1 1
15 22457711 Eimeripain, a cathepsin B-like cysteine protease, expressed throughout sporulation of the apicomplexan parasite Eimeria tenella. 2012 2
16 22093547 Inhibition of cathepsin B activity attenuates extracellular matrix degradation and inflammatory breast cancer invasion. 2011 2
17 20544024 Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei. 2010 Jun 8 2
18 19026616 Pre-clinical antitumour evaluation of Biphosphinic Palladacycle Complex in human leukaemia cells. 2009 Feb 12 1
19 19535915 A cathepsin L-specific inhibitor preferentially inhibits degradation of autophagosomal LC3 and GABARAP in HeLa and Huh-7 cells. 2009 Aug 1
20 18789614 Participation of cathepsin B in emodin-induced apoptosis in HK-2 Cells. 2008 Oct 1 1
21 17399759 Sensitization of vascular smooth muscle cell to TNF-alpha-mediated death in the presence of palmitate. 2007 May 1 1
22 17634228 Host cell cathepsins potentiate Moloney murine leukemia virus infection. 2007 Oct 1
23 16620747 Identification and discrimination of extracellularly active cathepsins B and L in high-invasive melanoma cells. 2006 Jun 1 2
24 16831419 Biphosphinic palladacycle complex mediates lysosomal-membrane permeabilization and cell death in K562 leukaemia cells. 2006 Aug 7 1
25 15586230 Differential susceptibility of metastatic and primary oral cancer cells to TRAIL-induced apoptosis. 2005 Jan 1
26 16051222 Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B. 2005 Aug 15 1
27 16164418 Inhibition of cathepsin B reduces beta-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate beta-secretase of Alzheimer's disease. 2005 Sep 1
28 12581740 Intracellular and extracellular cathepsin B facilitate invasion of MCF-10A neoT cells through reconstituted extracellular matrix in vitro. 2003 Feb 15 1
29 11815600 Phorbol ester activation of a proteolytic cascade capable of activating latent transforming growth factor-betaL a process initiated by the exocytosis of cathepsin B. 2002 Apr 26 2
30 11258881 Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities. 2001 Mar 6 1
31 11309313 An intracellular form of cathepsin B contributes to invasiveness in cancer. 2001 Apr 15 2
32 11327703 Significance of cathepsin B accumulation in synovial fluid of rheumatoid arthritis. 2001 May 4 2
33 11517939 Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design. 2001 May 1
34 10662686 Selective targeting of lysosomal cysteine proteases with radiolabeled electrophilic substrate analogs. 2000 Jan 1
35 10936287 Inhibitory effect of cathepsin B inhibitor CA 074 on mouse anti-rat mixed lymphocyte reaction: novel immunosuppressive strategy for indirect xenoantigen recognition. 2000 Aug 1
36 10951198 Biochemical characterization of human cathepsin X revealed that the enzyme is an exopeptidase, acting as carboxymonopeptidase or carboxydipeptidase. 2000 Sep 1
37 10380357 Structural basis of inhibition of cysteine proteases by E-64 and its derivatives. 1999 2
38 10447678 Exocytosis of active cathepsin B enzyme activity at pH 7.0, inhibition and molecular mass. 1999 Aug 2
39 10543449 Fluorometric microassays for the determination of cathepsin L and cathepsin S activities in tissue extracts. 1999 Sep 2
40 9546050 X-ray crystal structure of papain complexed with cathepsin B-specific covalent-type inhibitor: substrate specificity and inhibitory activity. 1998 Mar 3 1
41 9751144 Inhibition of ischaemic hippocampal neuronal death in primates with cathepsin B inhibitor CA-074: a novel strategy for neuroprotection based on 'calpain-cathepsin hypothesis'. 1998 May 2
42 9762356 Novel physiological functions of cathepsins B and L on antigen processing and osteoclastic bone resorption. 1998 1
43 9099961 Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung. 1997 1
44 8645703 Cathepsin B activity in normal human osteoblast-like cells and human osteoblastic osteosarcoma cells (MG-63): regulation by interleukin-1 beta and parathyroid hormone. 1996 May 21 1
45 8814458 Cathepsin B in gingival crevicular fluid of adult periodontitis patients: identification by immunological and enzymological methods. 1996 Jun 1
46 7584919 Role of cathepsin B as prorenin processing enzyme in human kidney. 1995 Jun 1
47 7721331 Both cathepsin B and cathepsin D are necessary for processing of ovalbumin as well as for degradation of class II MHC invariant chain. 1994 Dec 1
48 8393661 Activation of procathepsin B in human hepatoma cells: the conversion into the mature enzyme relies on the action of cathepsin B itself. 1993 Jul 15 1