Tyrosine

interleukin 3 ; Homo sapiens







77 Article(s)
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1 23991218 High yield production of a soluble human interleukin-3 variant from E. coli with wild-type bioactivity and improved radiolabeling properties. 2013 1
2 18628457 Transformation by oncogenic mutants and ligand-dependent activation of FLT3 wild-type requires the tyrosine residues 589 and 591. 2008 Jul 15 1
3 17638849 The Shc-binding site of the betac subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis. 2007 Nov 15 1
4 17027514 Transcription factors mediating interleukin-3 survival signals. 2006 1
5 15795318 {beta}1 Integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation. 2005 Mar 28 1
6 14730712 Signaling through JAK2-STAT5 pathway is essential for IL-3-induced activation of microglia. 2004 Jan 15 2
7 14500382 A novel small molecule met inhibitor induces apoptosis in cells transformed by the oncogenic TPR-MET tyrosine kinase. 2003 Sep 1 1
8 11495699 Prolactin-induced expression of cytokine-inducible SH2 signaling inhibitors in human hematopoietic progenitors. 2001 Aug 1
9 11593427 Involvement of Jak2 tyrosine phosphorylation in Bcr-Abl transformation. 2001 Sep 27 1
10 10671297 Tyrosine 462 of the membrane-proximal F'-G' loop of murine Mpl is not essential for high-affinity binding of thrombopoietin. 2000 Feb 2
11 10704825 Shc associates with the IL-3 receptor beta subunit, SHIP and Gab2 following IL-3 stimulation. Contribution of Shc PTB and SH2 domains. 2000 Mar 1
12 10891441 The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3. 2000 Jul 1 1
13 10993906 Identification of a novel immunoreceptor tyrosine-based activation motif-containing molecule, STAM2, by mass spectrometry and its involvement in growth factor and cytokine receptor signaling pathways. 2000 Dec 8 1
14 10194451 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells. 1999 Apr 15 1
15 10373548 SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. 1999 Jul 1
16 10378896 Signal transduction pathways in normal human monocytes stimulated by cytokines and mediators: comparative study with normal human neutrophils or transformed cells and the putative roles in functionality and cell biology. 1999 Jun 1
17 9596995 A phosphatidylcholine phospholipase C inhibitor, D609, blocks interleukin-3 (IL-3)-induced bcl-2 expression but not c-myc expression in human IL-3-dependent cells. 1998 May 1 1
18 9885438 Tyrosine phosphorylation of proteins in primary human myeloid leukemia cells stimulated by cytokines: analysis of the frequency of phosphorylation, and partial identification and semi-quantification of signaling molecules. 1998 Dec 1
19 8995358 Phosphorylation of Cbl following stimulation with interleukin-3 and its association with Grb2, Fyn, and phosphatidylinositol 3-kinase. 1997 Jan 10 2
20 9325013 Lack of correlation between growth of TF-1 cells and tyrosine phosphorylation signals in response to IL-3, IL-5 and GM-CSF. 1997 Sep 1
21 8671609 Critical proline residues of the cytoplasmic domain of the IL-5 receptor alpha chain and its function in IL-5-mediated activation of JAK kinase and STAT5. 1996 Feb 1
22 8677749 Proto-oncogene products Vav and c-Cbl are involved in the signal transduction through Grb2/Ash in hematopoietic cells. 1996 1
23 8780729 Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM. 1996 Aug 23 1
24 8806691 p91 STAT1 activation in interleukin-3-stimulated primary acute myeloid leukemia cells. 1996 Sep 5 1
25 8824238 A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all three ligands. 1996 Oct 18 1
26 7499252 Identification of a new adapter protein that may link the common beta subunit of the receptor for granulocyte/macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 to phosphatidylinositol 3-kinase. 1995 Nov 17 1
27 7530656 Tyrosine phosphorylation of p95Vav in myeloid cells is regulated by GM-CSF, IL-3 and steel factor and is constitutively increased by p210BCR/ABL. 1995 Jan 16 2
28 7534286 Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL. 1995 Mar 10 1
29 7534303 v-Abl-mediated apoptotic suppression is associated with SHC phosphorylation without concomitant mitogen-activated protein kinase activation. 1995 Mar 17 2
30 7539516 Diversity and similarity in signaling pathways of hematopoietic growth factors in human leukemia cell lines. 1995 May 1
31 7543102 Signal transduction by a CD16/CD7/Jak2 fusion protein. 1995 Aug 4 3
32 7545466 Evidence for a signaling role for the alpha chains of granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3), and IL-5 receptors: divergent signaling pathways between GM-CSF/IL-3 and IL-5. 1995 Oct 1 2
33 7545904 TPO and IL-3 induce overlapping but distinct protein tyrosine phosphorylation in a myeloid precursor cell line. 1995 Sep 14 2
34 7556524 Tyrosine phosphorylation and activation of focal adhesion kinase (p125FAK) by BCR-ABL oncoprotein. 1995 Oct 2
35 7566975 Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. 1995 Sep 21 1
36 7608147 Interleukin-3, erythropoietin, and prolactin activate a STAT5-like factor in lymphoid cells. 1995 Jul 7 1
37 7651724 Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain. 1995 Aug 17 1
38 7760829 Cloning of murine Stat6 and human Stat6, Stat proteins that are tyrosine phosphorylated in responses to IL-4 and IL-3 but are not required for mitogenesis. 1995 Jun 4
39 7796808 A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors. 1995 Jun 15 1
40 7836750 Human IL-3 receptor signaling: rapid induction of phosphatidylcholine hydrolysis is independent of protein kinase C but dependent on tyrosine phosphorylation in transfected NIH 3T3 cells. 1995 Feb 15 4
41 7515712 Association of p72 tyrosine kinase with Stat factors and its activation by interleukin-3, interleukin-6, and granulocyte colony-stimulating factor. 1994 Jun 15 1
42 7522233 Interleukin (IL)-3 and granulocyte/macrophage colony-stimulating factor, but not IL-4, induce tyrosine phosphorylation, activation, and association of SHPTP2 with Grb2 and phosphatidylinositol 3'-kinase. 1994 Sep 23 3
43 7526158 Tec kinase associates with c-kit and is tyrosine phosphorylated and activated following stem cell factor binding. 1994 Dec 2
44 7527392 Convergence of signaling by interleukin-3, granulocyte-macrophage colony-stimulating factor, and mast cell growth factor on JAK2 tyrosine kinase. 1994 Dec 16 1
45 7961995 Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor. 1994 Nov 25 2
46 8306341 Human interleukin-3 stimulates a phosphatidylcholine specific phospholipase C and protein kinase C translocation. 1994 Feb 1 1
47 7682176 c-fps/fes protein-tyrosine kinase is implicated in a signaling pathway triggered by granulocyte-macrophage colony-stimulating factor and interleukin-3. 1993 Apr 3
48 7691810 Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells. 1993 Oct 15 1
49 8255101 Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines. 1993 Dec 2
50 8378773 Tyrosine phosphorylation of DNA binding proteins by multiple cytokines. 1993 Sep 24 1