2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one

heme oxygenase 1 ; Homo sapiens







43 Article(s)
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1 35013107 Metformin prevents methylglyoxal-induced apoptosis by suppressing oxidative stress in vitro and in vivo. 2022 Jan 10 1
2 35281466 5,8-Dihydroxy-4 ', 7-dimethoxyflavone Attenuates TNF-α-Induced Expression of Vascular Cell Adhesion Molecule-1 through EGFR/PKCα/PI3K/Akt/Sp1-Dependent Induction of Heme Oxygenase-1 in Human Cardiac Fibroblasts. 2022 1
3 35605918 A diarylheptanoid compound from Alpinia officinarum Hance ameliorates high glucose-induced insulin resistance by regulating PI3K/AKT-Nrf2-GSK3β signaling pathways in HepG2 cells. 2022 Sep 15 1
4 33898501 Protective Effect of Chrysanthemum morifolium cv. Fubaiju Hot-Water Extracts Against ARPE-19 Cell Oxidative Damage by Activating PI3K/Akt-Mediated Nrf2/HO-1 Signaling Pathway. 2021 1
5 34202670 Cytoprotection against Oxidative Stress by Methylnissolin-3-O-β-d-glucopyranoside from Astragalus membranaceus Mainly via the Activation of the Nrf2/HO-1 Pathway. 2021 Jun 24 3
6 31669540 15-Keto prostaglandin E2 induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells. 2020 Jan 15 1
7 33023074 Short ELF-EMF Exposure Targets SIRT1/Nrf2/HO-1 Signaling in THP-1 Cells. 2020 Oct 2 1
8 30576222 Klotho protein inhibits H2O2-induced oxidative injury in endothelial cells via regulation of PI3K/AKT/Nrf2/HO-1 pathways. 2019 May 1
9 30709701 Oxyresveratrol protects human lens epithelial cells against hydrogen peroxide-induced oxidative stress and apoptosis by activation of Akt/HO-1 pathway. 2019 Mar 1
10 31056260 Osthole promotes the suppressive effects of cisplatin on NRF2 expression to prevent drug-resistant cervical cancer progression. 2019 Jun 25 1
11 31076999 Naringenin Inhibit the Hydrogen Peroxide-Induced SH-SY5Y Cells Injury Through Nrf2/HO-1 Pathway. 2019 Nov 1
12 31277394 Piceatannol Protects Human Retinal Pigment Epithelial Cells against Hydrogen Peroxide Induced Oxidative Stress and Apoptosis through Modulating PI3K/Akt Signaling Pathway. 2019 Jul 4 1
13 31351365 Naringenin-induced HO-1 ameliorates high glucose or free fatty acids-associated apoptosis via PI3K and JNK/Nrf2 pathways in human umbilical vein endothelial cells. 2019 Oct 1
14 29792861 Neuroligin-3 protects retinal cells from H2O2-induced cell death via activation of Nrf2 signaling. 2018 Jul 7 1
15 30097118 Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1. 2018 Jul 15 1
16 30280183 Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism. 2018 Dec 1
17 28612103 Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2/HO-1 signaling pathway. 2017 Aug 2
18 27313828 S-Propargyl-cysteine Exerts a Novel Protective Effect on Methionine and Choline Deficient Diet-Induced Fatty Liver via Akt/Nrf2/HO-1 Pathway. 2016 1
19 27323826 Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer. 2016 Jul 19 1
20 25917210 Geraniin exerts cytoprotective effect against cellular oxidative stress by upregulation of Nrf2-mediated antioxidant enzyme expression via PI3K/AKT and ERK1/2 pathway. 2015 Sep 1
21 25921464 c-Src-dependent transactivation of EGFR mediates CORM-2-induced HO-1 expression in human tracheal smooth muscle cells. 2015 Oct 1
22 26159150 Induction of Heme Oxygenase-1 by Sodium 9-Hydroxyltanshinone IIA Sulfonate Derivative Contributes to Inhibit LPS-Mediated Inflammatory Response in Macrophages. 2015 1
23 24361488 Nrf2/ARE pathway activation, HO-1 and NQO1 induction by polychlorinated biphenyl quinone is associated with reactive oxygen species and PI3K/AKT signaling. 2014 Feb 25 1
24 24442713 Angiotensin II-derived reactive oxygen species promote angiogenesis in human late endothelial progenitor cells through heme oxygenase-1 via ERK1/2 and AKT/PI3K pathways. 2014 Jun 1
25 23328493 A novel compound derived from danshensu inhibits apoptosis via upregulation of heme oxygenase-1 expression in SH-SY5Y cells. 2013 Apr 1
26 24094245 PI3K/Akt pathway mediates Nrf2/ARE activation in human L02 hepatocytes exposed to low-concentration HBCDs. 2013 1
27 24260155 Estrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cells. 2013 1
28 21971692 Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. 2012 Apr 2
29 22019695 Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. 2012 Feb 1
30 22943759 [The protective effect of chlorophyllin against oxidative damage and its mechanism]. 2012 Jun 1
31 23026832 Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells. 2012 Nov 15 1
32 23187004 Synergistic inhibition of mesothelioma cell growth by the combination of clofarabine and resveratrol involves Nrf2 downregulation. 2012 Nov 1
33 21620964 An IκBα phosphorylation inhibitor induces heme oxygenase-1(HO-1) expression through the activation of reactive oxygen species (ROS)-Nrf2-ARE signaling and ROS-PI3K/Akt signaling in an NF-κB-independent mechanism. 2011 Sep 1
34 20536682 Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells. 2010 Sep 1
35 20558128 Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling. 2010 Sep 1 1
36 20875851 Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway. 2010 Dec 1 2
37 18923065 YC-1 stimulates the expression of gaseous monoxide-generating enzymes in vascular smooth muscle cells. 2009 Jan 1
38 18021765 Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury. 2008 Feb 2 1
39 18048804 Acrolein induces heme oxygenase-1 through PKC-delta and PI3K in human bronchial epithelial cells. 2008 Apr 1
40 18598766 Resistance to anti-xenogeneic response by combining alpha-Gal silencing with HO-1 upregulation. 2008 Jul 1
41 17307160 Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells. 2007 Apr 10 1
42 17675106 Akt-dependent heme oxygenase-1 induction by NS-398 in C6 glial cells: a potential role for CO in prevention of oxidative damage from hypoxia. 2007 Sep 1
43 15965068 Celecoxib induces heme-oxygenase expression in glomerular mesangial cells. 2005 May 1