Title : Transforming growth factor-beta1 stimulates heme oxygenase-1 expression via the PI3K/Akt and NF-kappaB pathways in human lung epithelial cells.

Pub. Date : 2007 Apr 10

PMID : 17307160






1 Functional Relationships(s)
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1 Treatment of A549 cells with LY 294002 (2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, a PI3K inhibitor), an Akt inhibitor, and the dominant negative mutant of Akt (Akt DN) inhibited TGF-beta1-induced HO-1 expression and HO-1-luciferase activity. 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one heme oxygenase 1 Homo sapiens