| 1 |
34714577 | Stemness and immune evasion conferred by the TDO2-AHR pathway are associated with liver metastasis of colon cancer. | 2022 Jan |
2 |
| 2 |
34978092 | A review of chromatographic methods for bioactive tryptophan metabolites, kynurenine, kynurenic acid, quinolinic acid, and others, in biological fluids. | 2022 May |
2 |
| 3 |
35051612 | Indoleamine dioxygenase and tryptophan dioxygenase activities are regulated through GAPDH- and Hsp90-dependent control of their heme levels. | 2022 Feb 20 |
2 |
| 4 |
35056756 | MiR-126-5p Promotes Tumor Cell Proliferation, Metastasis and Invasion by Targeting TDO2 in Hepatocellular Carcinoma. | 2022 Jan 10 |
1 |
| 5 |
35064560 | Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status. | 2022 Mar |
2 |
| 6 |
35173722 | Targeting Tryptophan Catabolism in Cancer Immunotherapy Era: Challenges and Perspectives. | 2022 |
2 |
| 7 |
35358772 | Discovery and biological evaluation of tanshinone derivatives as potent dual inhibitors of indoleamine 2, 3-dioxygenase 1 and tryptophan 2, 3-dioxygenase. | 2022 May 5 |
4 |
| 8 |
35545044 | A pan-cancer metabolic atlas of the tumor microenvironment. | 2022 May 10 |
1 |
| 9 |
35563591 | Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model. | 2022 May 6 |
1 |
| 10 |
32707579 | Resistance Exercise Modulates Kynurenine Pathway in Pancreatic Cancer Patients. | 2021 Jan |
1 |
| 11 |
32840656 | The introduction of immunosuppressor (TDO inhibitor) significantly improved the efficacy of irinotecan in treating hepatocellular carcinoma. | 2021 Feb |
3 |
| 12 |
33373218 | Conformational Plasticity in Human Heme-Based Dioxygenases. | 2021 Feb 3 |
1 |
| 13 |
33418116 | Tryptophan and indole metabolism in immune regulation. | 2021 Jun |
2 |
| 14 |
33460767 | Role of tryptophan metabolism in cancers and therapeutic implications. | 2021 Mar |
4 |
| 15 |
33707411 | Metabolomic analyses of COVID-19 patients unravel stage-dependent and prognostic biomarkers. | 2021 Mar 11 |
1 |
| 16 |
33741464 | Discovery of 5-(N-hydroxycarbamimidoyl) benzofuran derivatives as novel indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors. | 2021 May 15 |
1 |
| 17 |
33842334 | Cancer Associated Fibroblasts Promote Renal Cancer Progression Through a TDO/Kyn/AhR Dependent Signaling Pathway. | 2021 |
4 |
| 18 |
33846800 | Tryptophan 2, 3‑dioxygenase promotes proliferation, migration and invasion of ovarian cancer cells. | 2021 Jun |
2 |
| 19 |
33870196 | Inhibition of tryptophan 2,3-dioxygenase impairs DNA damage tolerance and repair in glioma cells. | 2021 Jun |
4 |
| 20 |
34223158 | Recent advances in the development of AHR antagonists in immuno-oncology. | 2021 Jun 23 |
1 |
| 21 |
34251022 | Multiple roles of haem in cystathionine β-synthase activity: implications for hemin and other therapies of acute hepatic porphyria. | 2021 Jul 30 |
1 |
| 22 |
34338527 | Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase. | 2021 Aug 12 |
1 |
| 23 |
34423034 | TDO2 Was Downregulated in Hepatocellular Carcinoma and Inhibited Cell Proliferation by Upregulating the Expression of p21 and p27. | 2021 |
2 |
| 24 |
34511126 | Kynurenine pathway in post-mortem prefrontal cortex and cerebellum in schizophrenia: relationship with monoamines and symptomatology. | 2021 Sep 12 |
1 |
| 25 |
34657635 | Constitutive TDO2 expression promotes liver cancer progression by an autocrine IL-6 signaling pathway. | 2021 Oct 17 |
2 |
| 26 |
34720020 | Tryptophan 2,3-dioxygenase, a novel therapeutic target for Parkinson's disease. | 2021 Oct |
1 |
| 27 |
31819194 | The therapeutic potential of targeting tryptophan catabolism in cancer. | 2020 Jan |
2 |
| 28 |
31870154 | Modeling Tryptophan/Indoleamine 2,3-Dioxygenase with Heme Superoxide Mimics: Is Ferryl the Key Intermediate? | 2020 Jan 29 |
2 |
| 29 |
32117235 | Activation of the Kynurenine Pathway in Human Malignancies Can Be Suppressed by the Cyclin-Dependent Kinase Inhibitor Dinaciclib. | 2020 |
2 |
| 30 |
32292562 | Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors. | 2020 Apr 9 |
1 |
| 31 |
32296044 | Both IDO1 and TDO contribute to the malignancy of gliomas via the Kyn-AhR-AQP4 signaling pathway. | 2020 Feb 21 |
4 |
| 32 |
32606795 | TDO Promotes Hepatocellular Carcinoma Progression. | 2020 |
3 |
| 33 |
32842609 | The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents. | 2020 Aug 22 |
2 |
| 34 |
33045014 | Hepatocyte-intrinsic type I interferon signaling reprograms metabolism and reveals a novel compensatory mechanism of the tryptophan-kynurenine pathway in viral hepatitis. | 2020 Oct |
2 |
| 35 |
33178611 | Tryptophan Catabolism and Response to Therapy in Locally Advanced Rectal Cancer (LARC) Patients. | 2020 |
1 |
| 36 |
30213797 | Reversal of Triple-Negative Breast Cancer EMT by miR-200c Decreases Tryptophan Catabolism and a Program of Immunosuppression. | 2019 Jan |
1 |
| 37 |
30240768 | Expression of the IDO1/TDO2-AhR pathway in tumor cells or the tumor microenvironment is associated with Merkel cell polyomavirus status and prognosis in Merkel cell carcinoma. | 2019 Feb |
1 |
| 38 |
30952082 | Pt(IV) hybrids containing a TDO inhibitor serve as potential anticancer immunomodulators. | 2019 Jun |
1 |
| 39 |
31488951 | The Plasma [Kynurenine]/[Tryptophan] Ratio and Indoleamine 2,3-Dioxygenase: Time for Appraisal. | 2019 |
1 |
| 40 |
31866995 | Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma. | 2019 |
1 |
| 41 |
29254698 | Targeting the IDO1/TDO2-KYN-AhR Pathway for Cancer Immunotherapy - Challenges and Opportunities. | 2018 Mar |
4 |
| 42 |
29320557 | High AHR expression in breast tumors correlates with expression of genes from several signaling pathways namely inflammation and endogenous tryptophan metabolism. | 2018 |
1 |
| 43 |
29795752 | Aminoisoxazoles as Potent Inhibitors of Tryptophan 2,3-Dioxygenase 2 (TDO2). | 2018 May 10 |
2 |
| 44 |
29807576 | Genetic alterations affecting the genes encoding the enzymes of the kynurenine pathway and their association with human diseases. | 2018 Apr - Jun |
2 |
| 45 |
29959909 | Development of a mass spectrometry-based tryptophan 2, 3-dioxygenase assay using liver cytosol from multiple species. | 2018 Sep 1 |
1 |
| 46 |
30010674 | Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme. | 2018 Sep |
3 |
| 47 |
30014175 | IDO and TDO as a potential therapeutic target in different types of depression. | 2018 Dec |
1 |
| 48 |
30068361 | Targeting the IDO1 pathway in cancer: from bench to bedside. | 2018 Aug 2 |
2 |
| 49 |
30141341 | A validated surrogate analyte LC-MS/MS assay for quantitation of endogenous kynurenine and tryptophan in human plasma. | 2018 Aug 1 |
3 |
| 50 |
26617070 | Tryptophan availability for kynurenine pathway metabolism across the life span: Control mechanisms and focus on aging, exercise, diet and nutritional supplements. | 2017 Jan |
1 |