osimertinib

epidermal growth factor receptor ; Homo sapiens







727 Article(s)
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51 35081725 Novel mutation signatures in the prognosis of EGFR-TKIs targeted therapy for non-small cell lung cancer patients based on the 1000-gene panel sequencing. 2022 Mar 1
52 35088537 Durable response to durvalumab-based immunochemotherapy in small-cell lung carcinoma transformation from EGFR-mutant non-small cell lung cancer: A case report. 2022 Mar 2
53 35102249 Overcoming acquired resistance to third-generation EGFR inhibitors by targeting activation of intrinsic apoptotic pathway through Mcl-1 inhibition, Bax activation, or both. 2022 Mar 5
54 35105467 [Drug-drug interactions of tyrosine kinase inhibitors in treatment of non-small-cell lung carcinoma]. 2022 Mar 1
55 35106279 Effective treatment of pulmonary adenocarcinoma harboring triple EGFR mutations of L858R, T790M, cis-G796s/cis-C797s by osimertinib, brigatinib, and bevacizumab combination therapy: A case report. 2022 4
56 35112017 Non-small cell lung cancer with iris metastasis controlled with osimertinib and monthly intravitreal bevacizumab. 2022 Mar 1
57 35119858 Deciphering the Mechanism of Binding Selectivity of Chlorofluoroacetamide-Based Covalent Inhibitors toward L858R/T790M Resistance Mutation. 2022 Feb 28 2
58 35144338 [Survival analysis of different kinds of tyrosine kinase inhibitors in the treatment of patients with epidermal growth factor receptor mutated non-small cell lung cancer and leptomeningeal metastasis]. 2022 Feb 15 1
59 35146920 Acute fulminant hepatitis associated with osimertinib administration in a lung cancer patient with chronic hepatitis B: The first mortality case report. 2022 Apr 2
60 35156036 Osimertinib in advanced EGFR-mutant lung adenocarcinoma with asymptomatic brain metastases: an open-label, 3-arm, phase II pilot study. 2022 Jan-Dec 2
61 35159036 Targeted Therapy for Older Patients with Non-Small Cell Lung Cancer: Systematic Review and Guidelines from the French Society of Geriatric Oncology (SoFOG) and the French-Language Society of Pulmonology (SPLF)/French-Language Oncology Group (GOLF). 2022 Feb 2 1
62 35168607 Exosomes derived from M2 type tumor-associated macrophages promote osimertinib resistance in non-small cell lung cancer through MSTRG.292666.16-miR-6836-5p-MAPK8IP3 axis. 2022 Feb 15 2
63 35173881 Efficacy and mechanism of osimertinib combined with bevacizumab in the treatment of postoperative EGFR positive stage II-IIIA lung adenocarcinoma. 2022 2
64 35189835 Clinical outcomes of advanced non-small cell lung cancer patients harboring distinct subtypes of EGFR mutations and receiving first-line tyrosine kinase inhibitors: brain metastasis and de novo T790M matters. 2022 Feb 21 1
65 35194503 Treatment of Choroidal Metastasis from Epidermal Growth Factor Mutant Non-Small Cell Lung Cancer with First-line Osimertinib Therapy. 2022 Jan-Mar 3
66 35197546 Ibrutinib reverses IL-6-induced osimertinib resistance through inhibition of Laminin α5/FAK signaling. 2022 Feb 23 2
67 35201951 Epidermal growth factor receptor-Mutated Non-small-cell Lung Cancer with Intracranial Progressions and Stable Extracranial Diseases Benefit from Osimertinib Regardless of T790M Mutational Status. 2022 Jan-Dec 3
68 35208635 Successful Management of Osimertinib-Induced Heart Failure. 2022 Feb 18 3
69 35242623 TP53 co-mutations as an independent prognostic factor in 2nd and further line therapy-EGFR mutated non-small cell lung cancer IV patients treated with osimertinib. 2022 Jan 1
70 35245845 EGFR-RAD51 fusion in lung adenocarcinoma with systemic and intracranial response to osimertinib: A case report and review of the literature. 2022 Apr 2
71 35251316 Molecular landscape of osimertinib resistance in patients and patient-derived preclinical models. 2022 1
72 35257278 Correction to: Osimertinib in poor performance status patients with T790M‑positive advanced non‑small‑cell lung cancer after progression of first- and second‑generation EGFR‑TKI treatments (NEJ032B). 2022 Apr 1
73 35261905 Effectiveness of afatinib in an NSCLC patient with EGFR mutation and early progression to osimertinib: a case report. 2022 Jan 2
74 35265776 Successful response to first-line treatment with osimertinib for choroidal metastasis from EGFR-mutated non-small-cell lung cancer. 2022 Jun 4
75 35266116 MET-Targeted Therapies and Clinical Outcomes: A Systematic Literature Review. 2022 Mar 3
76 35287683 Potential benefit of osismertinib plus bevacizumab in leptomeningeal metastasis with EGFR mutant non-small-cell lung cancer. 2022 Mar 14 2
77 35293747 Mapping Tyrosine Kinases Based on a TK Activity-Representing Peptide Library Reveals a Role for SRC in H1975 Drug Resistance. 2022 Apr 1 1
78 35294773 ADAURA: The Splash of Osimertinib in Adjuvant EGFR-Mutant Non-small Cell Lung Cancer. 2022 Jun 1
79 35323965 Final report on plasma ctDNA T790M monitoring during EGFR-TKI treatment in patients with EGFR mutant non-small cell lung cancer (JP-CLEAR trial). 2022 Mar 22 1
80 35343187 Safety of osimertinib in adult patients with metastatic epidermal growth factor receptor T790M mutation-positive non-small cell lung cancer: Results from a Phase IV study in India. 2022 Mar 3
81 35344648 Osimertinib Combined with Systemic Chemotherapy for EGFR Mutant, T790M-Negative, Non-Small Cell Lung Cancer Patients Who Develop Leptomeningeal Metastases with Extracranial Progression to Prior EGFR TKI. 2022 Mar 28 4
82 35347039 Real-world Afatinib Outcomes in Advanced Non-small Cell Lung Cancer Harboring EGFR Mutations. 2022 Apr 2
83 35347108 Osimertinib and anti-HER3 combination therapy engages immune dependent tumor toxicity via STING activation in trans. 2022 Mar 28 1
84 35348294 Rare ashy dermatosis-like hyperpigmentation associated with osimertinib. 2022 May 1
85 35365042 A non-small cell lung cancer (NSCLC) patient harboring a rare epidermal growth factor receptor (EGFR) L858R/V843I mutation complex benefited from osimertinib: a case report. 2022 Mar 6
86 35365043 Durable clinical benefit from afatinib in a lung adenocarcinoma patient with acquired EGFR L718V mutation-mediated resistance towards osimertinib: a case report and literature review. 2022 Mar 7
87 35378738 Fulminant myocarditis in a patient with a lung adenocarcinoma after the third dose of modern COVID-19 vaccine. A case report and literature review. 2022 Jun 3
88 35379563 An Analysis of 5-Level Version of EQ-5D Adjusting for Treatment Switching: The Case of Patients With Epidermal Growth Factor Receptor T790M-Positive Nonsmall Cell Lung Cancer Treated With Osimertinib. 2022 Apr 2 1
89 35386002 First and repeat rebiopsy for detecting EGFR T790M mutation in non-small-cell lung cancer: CS-Lung-003 prospective observational registry study. 2022 Apr 6 2
90 35399244 Potential treatment strategy for the rare osimertinib resistant EGFR L718Q mutation. 2022 Mar 1
91 35399574 EGFR-RAD51 gene fusion NSCLC responsiveness to different generation EGFR-TKIs: two cases and review of the literature. 2022 Mar 1
92 35402377 Combining EGFR-TKI With SAHA Overcomes EGFR-TKI-Acquired Resistance by Reducing the Protective Autophagy in Non-Small Cell Lung Cancer. 2022 2
93 35412115 Targeting Acquired and Intrinsic Resistance Mechanisms in Epidermal Growth Factor Receptor Mutant Non-Small-Cell Lung Cancer. 2022 Apr 6
94 35431558 Pancytopenia During Osimertinib Treatment in a Patient with EGFR-Mutated Non-Small Cell Lung Cancer. 2022 4
95 35431966 Chinese Herbal Medicine (Yiqi-Yangyin-Jiedu Decoction) Combined With Osimertinib as First-Line Treatment in EGFR Mutation-Positive Advanced Non-Small-Cell Lung Cancer (CATLA-2): A Study Protocol for a Double-Blind Randomized Controlled Trial. 2022 1
96 35445633 Three Third-Generation Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer: Similarities and Differences. 2022 Apr 26 2
97 35446957 First-line therapy in non-small cell lung cancer patients with EGFR activating mutations: a consideration of the clinical position of osimertinib based on the subset of Japanese patients in the FLAURA study. 2022 Apr 22 2
98 35449204 Therapeutic efficacy of the novel SHP2 degrader SHP2-D26, alone or in combination, against lung cancer is associated with modulation of p70S6K/S6, Bim and Mcl-1. 2022 Apr 21 3
99 35461372 Combining plasma extracellular vesicle Let-7b-5p, miR-184 and circulating miR-22-3p levels for NSCLC diagnosis and drug resistance prediction. 2022 Apr 23 1
100 35462930 Acquired Concurrent EGFR T790M and Driver Gene Resistance From EGFR-TKIs Hampered Osimertinib Efficacy in Advanced Lung Adenocarcinoma: Case Reports. 2022 3