Cisplatin

thymidylate synthetase ; Homo sapiens







39 Article(s)
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1 31630149 Nitroglycerin Enhances Cisplatin-Induced Cytotoxicity via AKT Inactivation and Thymidylate Synthase Downregulation in Human Lung Cancer Cells. 2020 5
2 33024525 Relationship between the Expression of the Thymidylate Synthase and the Prognosis of Gastric Cancer Patients Treated with Combinational Chemotherapy Regimen Including Fluorouracil, Docetaxel and Cisplatin. 2020 Jul 1 1
3 33447420 Plasma thymidylate synthase and dihydrofolate reductase mRNA levels as potential predictive biomarkers of pemetrexed sensitivity in patients with advanced non-small cell lung cancer. 2020 Dec 2
4 27885848 Conveying a newly designed hydrophilic anti-human thymidylate synthase peptide to cisplatin resistant cancer cells: are pH-sensitive liposomes more effective than conventional ones? 2017 Mar 2
5 27666600 Salinomycin enhances cisplatin-induced cytotoxicity in human lung cancer cells via down-regulation of AKT-dependent thymidylate synthase expression. 2016 Dec 15 6
6 27821078 Vorinostat enhances the cisplatin-mediated anticancer effects in small cell lung cancer cells. 2016 Nov 7 1
7 25888862 Retraction note: Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients. 2015 Mar 26 1
8 26124486 Pemetrexed Plus Cisplatin Versus Gemcitabine Plus Cisplatin According to Thymidylate Synthase Expression in Nonsquamous Non-Small-Cell Lung Cancer: A Biomarker-Stratified Randomized Phase II Trial. 2015 Aug 1 4
9 26433347 Enhanced anti-hyperproliferative activity of human thymidylate synthase inhibitor peptide by solid lipid nanoparticle delivery. 2015 Dec 1 2
10 25223338 Joint detection of ERCC1, TUBB3, and TYMS guidance selection of docetaxel, 5-fluorouracil and cisplatin (DDP) individual chemotherapy in advanced gastric cancer patients. 2014 Sep 16 1
11 23523421 Thymidylate synthase and ERCC1 as predictive markers in patients with pulmonary adenocarcinoma treated with pemetrexed and cisplatin. 2013 Jul 3
12 23790173 Individualized treatment of NSCLC: from research to clinical practice. 2013 1
13 23903781 Modulation of the expression of folate cycle enzymes and polyamine metabolism by berberine in cisplatin-sensitive and -resistant human ovarian cancer cells. 2013 Oct 2
14 21444628 Up-regulation of extracellular signal-regulated kinase 1/2-dependent thymidylate synthase and thymidine phosphorylase contributes to cisplatin resistance in human non-small-cell lung cancer cells. 2011 Jul 1
15 20857529 A predictive factor for the response to S-1 plus cisplatin in gastric cancer. 2010 Sep 28 3
16 19446547 Collateral sensitivity to novel thymidylate synthase inhibitors correlates with folate cycle enzymes impairment in cisplatin-resistant human ovarian cancer cells. 2009 Aug 1 4
17 19638079 Pharmacogenetics of fluoropyrimidine and cisplatin. A future application to gastric cancer treatment. 2009 Jun 1
18 17211470 Immunostaining of thymidylate synthase and p53 for predicting chemoresistance to S-1/cisplatin in gastric cancer. 2007 Jan 29 3
19 16317430 Polymorphisms of glutathione S-transferases (GST) and thymidylate synthase (TS)--novel predictors for response and survival in gastric cancer patients. 2006 Jan 30 1
20 16612157 [Experimental chemotherapy against human esophageal carcinoma xenografts with TS-1, cisplatin and docetaxel]. 2006 Apr 1
21 16809149 Thymidylate synthase and dihydropyrimidine dehydrogenase are related to histological effects of 5-fluorouracil and cisplatin neoadjuvant chemotherapy for primary gastric cancer patients. 2006 Apr-May 2
22 16918130 Transplatin, a cisplatin trans-isomer, may enhance the anticancer effect of 5-fluorouracil. 2006 Jun 1
23 15224198 Changes in thymidylate synthase and its inhibition rate and changes in dihydropyrimidine dehydrogenase after the administration of 5-fluorouracil with cisplatin to nude mice with gastric cancer xenograft SC-1-NU. 2004 2
24 11321346 Gastric cancer with Virchow's and multiple lung metastases showing a remarkable response to preoperative chemotherapy: report of a case. 2001 1
25 11705873 Characterization of a thymidylate synthase (TS)-inducible cell line: a model system for studying sensitivity to TS- and non-TS-targeted chemotherapies. 2001 Nov 1
26 10499641 Low-dose cisplatin and 5-fluorouracil in combination can repress increased gene expression of cellular resistance determinants to themselves. 1999 Sep 2
27 10632346 Prognostic value of p53, glutathione S-transferase pi, and thymidylate synthase for neoadjuvant cisplatin-based chemotherapy in head and neck cancer. 1999 Dec 1
28 9440758 ERCC1 mRNA levels complement thymidylate synthase mRNA levels in predicting response and survival for gastric cancer patients receiving combination cisplatin and fluorouracil chemotherapy. 1998 Jan 2
29 9589051 [Effect of low-dose CDDP/5-FU therapy on thymidylate synthase content]. 1998 Apr 1
30 9644315 [Thymidylate synthase expression in patients with hypopharyngeal carcinoma]. 1998 Jun 1
31 8949986 Synergy between the non-classical thymidylate synthase inhibitor AG337 (Thymitaq) and cisplatin in human colon and ovarian cancer cells. 1996 Sep 1
32 7646933 Relationships between resistance to cisplatin and antifolates in sensitive and resistant tumour cell lines. 1995 Jun 3
33 7882343 Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. 1995 Apr 1 1
34 8021136 Thymidylate synthase activity, folates, and glutathione system in head and neck carcinoma and adjacent tissues. 1994 Mar-Apr 1
35 1727369 Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. 1992 Jan 1 1
36 2730661 Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells. 1989 May 30 1
37 3167836 Detection of drug resistance in human tumors by in vitro enzymatic amplification. 1988 Oct 15 1
38 3337743 Mechanisms of cross-resistance to methotrexate and 5-fluorouracil in an A2780 human ovarian carcinoma cell subline resistant to cisplatin. 1988 Feb 1 1
39 3422447 Elevated expression of thymidylate synthase cycle genes in cisplatin-resistant human ovarian carcinoma A2780 cells. 1988 Feb 3