Arsenic Trioxide

AKT serine/threonine kinase 1 ; Homo sapiens







65 Article(s)
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1 33858507 Arsenic trioxide synergistically promotes the antileukaemic activity of venetoclax by downregulating Mcl-1 in acute myeloid leukaemia cells. 2021 Apr 15 1
2 34749590 Mutated JAK2 signal transduction in human Induced Pluripotent Stem Cell (iPSC)-derived Megakaryocytes. 2021 Nov 9 1
3 34880920 Exploring the Mechanisms of Arsenic Trioxide (Pishuang) in Hepatocellular Carcinoma Based on Network Pharmacology. 2021 1
4 32169580 Activation of PPARγ intensified the effects of arsenic trioxide in acute promyelocytic leukemia through the suppression of PI3K/Akt pathway: Proposing a novel anticancer effect for pioglitazone. 2020 May 1
5 32184170 Exposure of low-concentration arsenic induces myotube atrophy by inhibiting an Akt signaling pathway. 2020 Jun 2
6 32305283 Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells. 2020 Apr 17 5
7 29574283 VS-5584 as a PI3K/mTOR inhibitor enhances apoptotic effects of subtoxic dose arsenic trioxide via inhibition of NF-κB activity in B cell precursor-acute lymphoblastic leukemia. 2018 Jun 2
8 30213730 The suppressive effect of arsenic trioxide on TET2-FOXP3-Lyn-Akt axis-modulated MCL1 expression induces apoptosis in human leukemia cells. 2018 Nov 1 5
9 30250637 Combination of ATO with FLT3 TKIs eliminates FLT3/ITD+ leukemia cells through reduced expression of FLT3. 2018 Aug 31 1
10 30554581 [Knockdown of SOX9 enhances apoptosis of laryngeal squamous cell carcinoma cells induced by As2O3]. 2018 Oct 1
11 28355296 Tetraarsenic hexoxide induces G2/M arrest, apoptosis, and autophagy via PI3K/Akt suppression and p38 MAPK activation in SW620 human colon cancer cells. 2017 2
12 29442453 Transcriptomic analysis of the PI3K/Akt signaling pathway reveals the dual role of the c-Jun oncogene in cytotoxicity and the development of resistance in HL-60 leukemia cells in response to arsenic trioxide. 2017 Dec 3
13 27189198 Chemosensitivity enhancement toward arsenic trioxide by inhibition of histone deacetylase in NB4 cell line. 2016 Aug 1
14 28024471 [Combination of Homoharringtonine with Arsenic Trioxide Induces Apoptosis of Human Acute Myeloid Leukemia Cell Line U937]. 2016 Dec 1
15 25416439 Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. 2015 Apr 5
16 25758096 The mechanism of synergistic effects of arsenic trioxide and rapamycin in acute myeloid leukemia cell lines lacking typical t(15;17) translocation. 2015 Jul 1
17 25791921 TG-interacting factor transcriptionally induced by AKT/FOXO3A is a negative regulator that antagonizes arsenic trioxide-induced cancer cell apoptosis. 2015 May 15 3
18 25869069 Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways. 2015 May 29 1
19 26038719 Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line. 2015 1
20 26062301 The synergistic killing of AML cells co-cultured with HS-5 bone marrow stromal cells by As2O3 and the PI3K/Akt signaling pathway inhibitor LY294002. 2015 May 1
21 26359868 Low-Concentration Arsenic Trioxide Inhibits Skeletal Myoblast Cell Proliferation via a Reactive Oxygen Species-Independent Pathway. 2015 3
22 24307199 Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation. 2014 Feb 1
23 24482137 Inactivation of Akt by arsenic trioxide induces cell death via mitochondrial-mediated apoptotic signaling in SGC-7901 human gastric cancer cells. 2014 Apr 9
24 24750786 Glioblastoma stem cells: a new target for metformin and arsenic trioxide. 2014 Jan-Mar 1
25 24791595 The effect to IL-3Ralpha, downstream PI3k/Akt signaling of all-trans retinoic acid and arsenic trioxide in NB4 cells. 2014 Apr 2
26 25506699 Apoptotic efficacy of etomoxir in human acute myeloid leukemia cells. Cooperation with arsenic trioxide and glycolytic inhibitors, and regulation by oxidative stress and protein kinase activities. 2014 2
27 22751450 Downregulation of Mcl-1 through GSK-3β activation contributes to arsenic trioxide-induced apoptosis in acute myeloid leukemia cells. 2013 Feb 1
28 23178716 SnoN/SkiL expression is modulated via arsenic trioxide-induced activation of the PI3K/AKT pathway in ovarian cancer cells. 2013 Jan 4 3
29 23201927 Cardioprotective effect of salvianolic acid B against arsenic trioxide-induced injury in cardiac H9c2 cells via the PI3K/Akt signal pathway. 2013 Feb 4 1
30 23255002 Inhibition of rapamycin-induced Akt phosphorylation by cotylenin A correlates with their synergistic growth inhibition of cancer cells. 2013 Feb 2
31 23352504 Inhibition of AKT enhances mitotic cell apoptosis induced by arsenic trioxide. 2013 Mar 15 9
32 23542114 Arsenic trioxide depletes cancer stem-like cells and inhibits repopulation of neurosphere derived from glioblastoma by downregulation of Notch pathway. 2013 Jun 20 1
33 23548265 Synergistic anticancer activity of arsenic trioxide with erlotinib is based on inhibition of EGFR-mediated DNA double-strand break repair. 2013 Jun 1
34 23911876 Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. 2013 Oct 5 11
35 23980369 [Homoharringtonine combined arsenic trioxide induced apoptosis in human multiple myeloma cell line RPMI 8226: an experimental research]. 2013 Jun 1
36 24161621 Differential sensitivity of p44/p42-MAPK- and PI3K/Akt-targeted neuroblastoma subtypes to arsenic trioxide. 2013 Dec 1
37 24392034 Arsenic trioxide overcomes rapamycin-induced feedback activation of AKT and ERK signaling to enhance the anti-tumor effects in breast cancer. 2013 6
38 21947421 Synergistic antitumor activity of oridonin and arsenic trioxide on hepatocellular carcinoma cells. 2012 Jan 1
39 22391160 [Regulation of all-trans retinoic acid and arsenic trioxide on CD44v6 expression in NB4 cells]. 2012 Feb 3
40 23041229 2-Deoxy-D-glucose cooperates with arsenic trioxide to induce apoptosis in leukemia cells: involvement of IGF-1R-regulated Akt/mTOR, MEK/ERK and LKB-1/AMPK signaling pathways. 2012 Dec 15 1
41 23239002 Synergism between carnosic acid and arsenic trioxide on induction of acute myeloid leukemia cell apoptosis is associated with modulation of PTEN/Akt signaling pathway. 2012 Dec 1
42 21180886 E3 ubiquitin ligase Cbl-b potentiates the apoptotic action of arsenic trioxide by inhibiting the PI3K/Akt pathway. 2011 Feb 1
43 21594580 Arsenic trioxide induces autophagy and apoptosis in human glioma cells in vitro and in vivo through downregulation of survivin. 2011 Sep 2
44 21649584 Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. 2011 Sep 1 1
45 21655183 BIM-mediated AKT phosphorylation is a key modulator of arsenic trioxide-induced apoptosis in cisplatin-sensitive and -resistant ovarian cancer cells. 2011 4
46 21889928 Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. 2011 Dec 1 1
47 20534739 Induction of B-chronic lymphocytic leukemia cell apoptosis by arsenic trioxide involves suppression of the phosphoinositide 3-kinase/Akt survival pathway via c-jun-NH2 terminal kinase activation and PTEN upregulation. 2010 Sep 1 1
48 20622048 Arsenic trioxide and the phosphoinositide 3-kinase/akt pathway in chronic lymphocytic leukemia. 2010 Sep 1 3
49 20657188 Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. 2010 Sep 15 1
50 20862710 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. 2010 Dec 15 3