Pub. Date : 2020 Apr 17
PMID : 32305283
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Arsenic trioxide-induced p38 MAPK and Akt mediated MCL1 downregulation causes apoptosis of BCR-ABL1-positive leukemia cells. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | ATO-induced apoptotic death in K562 cells was characterized by ROS-mediated mitochondrial depolarization, MCL1 downregulation, p38 MAPK activation, and Akt inactivation. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | ATO-induced BCR-ABL1 downregulation caused Akt inactivation but not p38 MAPK activation. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Inhibition of p38 MAPK activation or overexpression of constitutively active Akt increased MCL1 expression and promoted the survival of ATO-treated cells. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Collectively, our data indicate that ATO-induced p38 MAPK- and Akt-mediated MCL1 downregulation triggers apoptosis in K562 and MEG-01 cells, and that p38 MAPK activation is independent of ATO-induced BCR-ABL1 suppression. | Arsenic Trioxide | AKT serine/threonine kinase 1 | Homo sapiens |