Title : A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer.

Pub. Date : 2022 Jan

PMID : 34735897






1 Functional Relationships(s)
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1 Pictilisib treatment inhibited the protein kinase B (AKT) cell survival pathway and promoted a pro-apoptotic phenotype as evidenced by quantitative real time polymerase chain reaction (qRT-PCR) analysis of the B-cell lymphoma 2 (BCL2) protein family members (P<0.01). 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine AKT serine/threonine kinase 1 Homo sapiens