Curcumin

AKT serine/threonine kinase 1 ; Homo sapiens







227 Article(s)
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51 33292283 Resveratrol, curcumin, paclitaxel and miRNAs mediated regulation of PI3K/Akt/mTOR pathway: go four better to treat bladder cancer. 2020 Nov 23 1
52 30392062 Curcumin ameliorates PRMT5-MEP50 arginine methyltransferase expression by decreasing the Sp1 and NF-YA transcription factors in the A549 and MCF-7 cells. 2019 May 1
53 30467667 Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells. 2019 Feb 3
54 30542713 Curcumin attenuates hyperglycemia-driven EGF-induced invasive and migratory abilities of pancreatic cancer via suppression of the ERK and AKT pathways. 2019 Jan 3
55 30569107 Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway. 2019 Feb 1
56 30727807 Curcumin regulates the miR-21/PTEN/Akt pathway and acts in synergy with PD98059 to induce apoptosis of human gastric cancer MGC-803 cells. 2019 Mar 4
57 30838091 An ingenious non-spherical mesoporous silica nanoparticle cargo with curcumin induces mitochondria-mediated apoptosis in breast cancer (MCF-7) cells. 2019 Feb 5 1
58 30984574 The neuroprotective effect of BSA-based nanocurcumin against 6-OHDA-induced cell death in SH-SY5Y cells. 2019 Mar-Apr 2
59 31006841 Curcumin induces apoptotic cell death and protective autophagy by inhibiting AKT/mTOR/p70S6K pathway in human ovarian cancer cells. 2019 Jun 2
60 31016760 Curcumin ameliorates atherosclerosis through upregulation of miR-126. 2019 Nov 2
61 31196210 Curcumin overcome primary gefitinib resistance in non-small-cell lung cancer cells through inducing autophagy-related cell death. 2019 Jun 13 1
62 31223280 Potential Mechanisms of Action of Curcumin for Cancer Prevention: Focus on Cellular Signaling Pathways and miRNAs. 2019 1
63 31275848 Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia. 2019 4
64 31295875 Role of Autophagy on Heavy Metal-Induced Renal Damage and the Protective Effects of Curcumin in Autophagy and Kidney Preservation. 2019 Jul 10 1
65 31316605 Curcumin suppresses intestinal microvascular endothelial cells invasion and angiogenesis induced by activated platelets. 2019 Aug 1
66 31511778 Curcumin Inhibits Joint Contracture through PTEN Demethylation and Targeting PI3K/Akt/mTOR Pathway in Myofibroblasts from Human Joint Capsule. 2019 1
67 31593984 Therapeutic Effect of Curcumin, a Plant Polyphenol Extracted From Curcuma longae, in Fibroblasts From Patients With Graves' Orbitopathy. 2019 Oct 1 1
68 31841506 Combination treatment of berberine and solid lipid curcumin particles increased cell death and inhibited PI3K/Akt/mTOR pathway of human cultured glioblastoma cells more effectively than did individual treatments. 2019 1
69 29328421 Antitumor activity of curcumin by modulation of apoptosis and autophagy in human lung cancer A549 cells through inhibiting PI3K/Akt/mTOR pathway. 2018 Mar 10
70 29512729 Curcumin inhibits superoxide dismutase-induced epithelial-to-mesenchymal transition via the PI3K/Akt/NF-κB pathway in pancreatic cancer cells. 2018 May 4
71 29533214 Curcumin analogue 1,5-bis(4-hydroxy-3-((4-methylpiperazin-1-yl)methyl)phenyl)penta-1,4-dien-3-one mediates growth arrest and apoptosis by targeting the PI3K/AKT/mTOR and PKC-theta signaling pathways in human breast carcinoma cells. 2018 Aug 1
72 29545895 Curcumin inhibits the growth of liver cancer stem cells through the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin signaling pathway. 2018 Apr 3
73 29578162 The autophagy induced by curcumin via MEK/ERK pathway plays an early anti-leukemia role in human Philadelphia chromosome-positive acute lymphoblastic leukemia SUP-B15 cells. 2018 1
74 29599831 Effect of curcumin on vascular endothelial growth factor in hypoxic HepG2 cells via the insulin-like growth factor 1 receptor signaling pathway. 2018 Mar 1
75 29614882 The Polyphenolic Compound Curcumin Conjugation with an Alkyne Moiety in the Process of Autophagy. 2018 2
76 29620257 Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway. 2018 Jul 2
77 29808357 IL-17A suppresses and curcumin up-regulates Akt expression upon bleomycin exposure. 2018 Aug 2
78 29849119 mTORC1/2 inhibitor and curcumin induce apoptosis through lysosomal membrane permeabilization-mediated autophagy. 2018 Sep 4
79 29950857 Curcumin suppresses the progression of laryngeal squamous cell carcinoma through the upregulation of miR-145 and inhibition of the PI3K/Akt/mTOR pathway. 2018 4
80 30056019 Heat shock protein 27 influences the anti-cancer effect of curcumin in colon cancer cells through ROS production and autophagy activation. 2018 Sep 15 2
81 30076255 Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ B and the serine/threonine kinase Akt and is independent of tubulin polymerization. 2018 Aug 3 1
82 30116377 Curcumin inhibits proliferation and promotes apoptosis of breast cancer cells. 2018 Aug 2
83 30226563 Downregulation of glucose-regulated protein 78 enhances the cytotoxic effects of curcumin on human nasopharyngeal carcinoma cells. 2018 Nov 1
84 30272283 Curcumin induces apoptosis and inhibits angiogenesis in murine malignant mesothelioma. 2018 Dec 2
85 30335638 Bromophenol curcumin analog BCA-5 exerts an antiangiogenic effect through the HIF-1α/VEGF/Akt signaling pathway in human umbilical vein endothelial cells. 2018 Nov 1
86 31949668 Curcumin suppresses gastric cancer biological activity by regulation of miRNA-21: an in vitro study. 2018 1
87 27829579 Curcumin Suppresses Epithelial-Mesenchymal Transition of Renal Tubular Epithelial Cells through the Inhibition of Akt/mTOR Pathway. 2017 Jan 1 4
88 28199187 Combinatorial effect of curcumin with docetaxel modulates apoptotic and cell survival molecules in prostate cancer. 2017 Mar 1 1
89 28286973 Curcumin inhibits urothelial tumor development by suppressing IGF2 and IGF2-mediated PI3K/AKT/mTOR signaling pathway. 2017 Aug 7
90 28291961 Attenuation of Oxidative Stress-Induced Osteoblast Apoptosis by Curcumin is Associated with Preservation of Mitochondrial Functions and Increased Akt-GSK3β Signaling. 2017 3
91 28478460 Curcumin Inhibits Heat-Induced Apoptosis by Suppressing NADPH Oxidase 2 and Activating the Akt/mTOR Signaling Pathway in Bronchial Epithelial Cells. 2017 3
92 28498433 Curcumin induces apoptotic cell death and protective autophagy in human gastric cancer cells. 2017 Jun 1
93 28599484 Anticancer effect of curcumin inhibits cell growth through miR-21/PTEN/Akt pathway in breast cancer cell. 2017 Jun 4
94 28728293 [Curcumin induces apoptosis and protective autophagy in human gastric cancer cells with different degree of differentiation]. 2017 Jul 23 1
95 28769986 Curcumin Induces p53-Null Hepatoma Cell Line Hep3B Apoptosis through the AKT-PTEN-FOXO4 Pathway. 2017 2
96 29085504 Curcumin inhibits cell proliferation and promotes apoptosis of laryngeal cancer cells through Bcl-2 and PI3K/Akt, and by upregulating miR-15a. 2017 Oct 4
97 29110611 Curcumin Inhibits Proliferation and Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells Via Multiple Pathways. 2017 Dec 7 1
98 29180881 Curcumin potentiates the potent antitumor activity of ACNU against glioblastoma by suppressing the PI3K/AKT and NF-κB/COX-2 signaling pathways. 2017 2
99 29201217 Curcumin inhibits the development of non-small cell lung cancer by inhibiting autophagy and apoptosis. 2017 Nov 1
100 29273065 Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. 2017 Dec 22 1