tretazicar

NAD(P)H quinone dehydrogenase 1 ; Homo sapiens







10 Article(s)
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1 16129418 Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954. 2005 Oct 14 1
2 14529407 CB 1954: from the Walker tumor to NQO2 and VDEPT. 2003 1
3 11361019 Demonstration of the activation of prodrug CB 1954 using human DT-diaphorase mutant Q104Y-transfected MDA-MB-231 cells and mouse xenograft model. 2001 Jan 1 1
4 10419545 Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling. 1999 Aug 1
5 10543876 Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954). 1999 Oct 21 2
6 10656629 Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs. 1999 Nov 15 7
7 9367528 Catalytic properties of NAD(P)H:quinone oxidoreductase-2 (NQO2), a dihydronicotinamide riboside dependent oxidoreductase. 1997 Nov 15 1
8 8375021 The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT). 1993 Jun 1
9 1449531 Potentiation of CB 1954 cytotoxicity by reduced pyridine nucleotides in human tumour cells by stimulation of DT diaphorase activity. 1992 Nov 3 2
10 1901207 The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) 1991 Mar 15-Apr 1 7