Pub. Date : 1999 Nov 15
PMID : 10656629
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Role of redox cycling and activation by DT-diaphorase in the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its analogs. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 2 | In tumor cell lines with high content of DT-diaphorase (EC 1.6.99.2), the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its derivatives is exerted through DT-diaphorase-catalyzed formation of crosslinking species. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 3 | In tumor cell lines with high content of DT-diaphorase (EC 1.6.99.2), the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its derivatives is exerted through DT-diaphorase-catalyzed formation of crosslinking species. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 4 | In tumor cell lines with high content of DT-diaphorase (EC 1.6.99.2), the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its derivatives is exerted through DT-diaphorase-catalyzed formation of crosslinking species. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 5 | In tumor cell lines with high content of DT-diaphorase (EC 1.6.99.2), the cytotoxicity of 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB-1954) and its derivatives is exerted through DT-diaphorase-catalyzed formation of crosslinking species. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 6 | Using multiparameter regression analysis, we have found that the toxicity of CB-1954 derivatives as well as that of several non-alkylating nitroaromatics, increased upon the increase in their single-electron reduction potential (E(1)7) and octanol/water partition coefficient (P), and almost did not depend on their reactivity towards DT-diaphorase. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |
| 7 | It seems that in cell lines with a moderate amount of DT-diaphorase, the toxicity of CB- 1954 and its analogs is exerted through their redox cycling. | tretazicar | NAD(P)H quinone dehydrogenase 1 | Homo sapiens |