| 1 |
35347544 | Review on NAD(P)H dehydrogenase quinone 1 (NQO1) pathway. | 2022 Mar 28 |
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33139492 | NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer. | 2021 Jan 25 |
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| 3 |
28236663 | Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1). | 2017 Apr |
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| 4 |
26424559 | Implications of NQO1 in cancer therapy. | 2015 Nov |
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| 5 |
22209713 | NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones. | 2012 Apr 15 |
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| 6 |
22522008 | COMPARE analysis of the toxicity of an iminoquinone derivative of the imidazo[5,4-f]benzimidazoles with NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and computational docking of quinones as NQO1 substrates. | 2012 May 15 |
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18618519 | Calcium and calcium sensing receptor modulates the expression of thymidylate synthase, NAD(P)H:quinone oxidoreductase 1 and survivin in human colon carcinoma cells: promotion of cytotoxic response to mitomycin C and fluorouracil. | 2009 Mar |
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| 8 |
19791750 | Reductive activation of mitomycin C by thiols: kinetics, mechanism, and biological implications. | 2009 Oct |
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| 9 |
18407955 | Phase II study of sequentially administered low-dose mitomycin-C (MMC) and irinotecan (CPT-11) in women with metastatic breast cancer (MBC). | 2008 Aug |
2 |
| 10 |
17518056 | [Metabolism of mitomycin C by human liver microsomes in vitro]. | 2007 Feb |
2 |
| 11 |
16494910 | Arsenite pretreatment enhances the cytotoxicity of mitomycin C in human cancer cell lines via increased NAD(P)H quinone oxidoreductase 1 expression. | 2006 Aug 1 |
4 |
| 12 |
17031400 | Reduction of mitomycin C is catalysed by human recombinant NRH:quinone oxidoreductase 2 using reduced nicotinamide adenine dinucleotide as an electron donating co-factor. | 2006 Nov 6 |
2 |
| 13 |
15877230 | Effect of NQO1 induction on the antitumor activity of RH1 in human tumors in vitro and in vivo. | 2005 Sep |
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| 14 |
14999778 | Immunohistochemical analysis of NAD(P)H:quinone oxidoreductase and NADPH cytochrome P450 reductase in human superficial bladder tumours: relationship between tumour enzymology and clinical outcome following intravesical mitomycin C therapy. | 2004 May 1 |
2 |
| 15 |
15375541 | NAD(P)H:Quinone oxidoreductase-1 C609T polymorphism analysis in human superficial bladder cancers: relationship of genotype status to NQO1 phenotype and clinical response to Mitomycin C. | 2004 Oct |
12 |
| 16 |
15467770 | Dietary induction of NQO1 increases the antitumour activity of mitomycin C in human colon tumours in vivo. | 2004 Oct 18 |
1 |
| 17 |
12588957 | NAD(P)H: quinone oxidoreductase 1 expression in kidney podocytes. | 2003 Mar |
4 |
| 18 |
12649308 | Kinetics of NAD(P)H:quinone oxidoreductase I (NQO1) inhibition by mitomycin C in vitro and in vivo. | 2003 Jun |
2 |
| 19 |
11773862 | Clinical significance of a NAD(P)H: quinone oxidoreductase 1 polymorphism in patients with disseminated peritoneal cancer receiving intraperitoneal hyperthermic chemotherapy with mitomycin C. | 2002 Jan |
6 |
| 20 |
11350900 | Expression of DT-diaphorase and cytochrome P450 reductase correlates with mitomycin C activity in human bladder tumors. | 2001 May |
3 |
| 21 |
11511688 | Overexpression of NAD(P)H:quinone oxidoreductase 1 in human reproductive system. | 2001 Sep |
3 |
| 22 |
11600935 | Immunohistochemical localization of NAD(P)H:quinone oxidoreductase in conjunctival melanomas and primary acquired melanosis. | 2001 May |
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| 23 |
11691791 | Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells. | 2001 Nov 1 |
5 |
| 24 |
11696818 | Distribution of DT-diaphorase and reduced nicotinamide adenine dinucleotide phosphate: cytochrome p450 oxidoreductase in bladder tissues and tumors. | 2001 Dec |
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| 25 |
11709197 | Genotyping of NAD(P)H:quinone oxidoreductase (NQO1) in a panel of human tumor xenografts: relationship between genotype status, NQO1 activity and the response of xenografts to Mitomycin C chemotherapy in vivo(1). | 2001 Nov 15 |
2 |
| 26 |
10845577 | Immunohistochemical localization of NQO1 in epithelial dysplasia and neoplasia and in donor eyes. | 2000 Jun |
6 |
| 27 |
11085512 | Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation. | 2000 Nov 1 |
1 |
| 28 |
11103802 | Predicting tumor responses to mitomycin C on the basis of DT-diaphorase activity or drug metabolism by tumor homogenates: implications for enzyme-directed bioreductive drug development. | 2000 Nov 15 |
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| 29 |
10376975 | Enhanced cytotoxicity of mitomycin C in human tumour cells with inducers of DT-diaphorase. | 1999 Jun |
6 |
| 30 |
10391098 | Regulatory network of mitomycin C action in human colon cancer cells. | 1999 May |
1 |
| 31 |
9523739 | Geldanamycin-induced cytotoxicity in human colon-cancer cell lines: evidence against the involvement of c-Src or DT-diaphorase. | 1998 |
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| 32 |
9579829 | Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents. | 1998 Apr |
2 |
| 33 |
9731717 | NAD(P)H:quinone oxidoreductase: polymorphisms and allele frequencies in Caucasian, Chinese and Canadian Native Indian and Inuit populations. | 1998 Aug |
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| 34 |
9748120 | Immunohistochemical detection of NAD(P)H:quinone oxidoreductase in human lung and lung tumors. | 1998 Sep |
1 |
| 35 |
9762350 | Exploring the mechanistic aspects of mitomycin antibiotic bioactivation in Chinese hamster ovary cells overexpressing NADPH:cytochrome C (P-450) reductase and DT-diaphorase. | 1998 |
2 |
| 36 |
9763215 | Enzymology of mitomycin C metabolic activation in tumour tissue: implications for enzyme-directed bioreductive drug development. | 1998 Aug 15 |
1 |
| 37 |
9788412 | Role of a DT-diaphorase mutation in the response of anal canal carcinoma to radiation, 5-fluorouracil, and mitomycin C. | 1998 Sep 1 |
3 |
| 38 |
9792212 | Current issues in the enzymology of mitomycin C metabolic activation. | 1998 Oct |
2 |
| 39 |
9818026 | Immunological quantitation of DT-diaphorase in carcinoma cell lines and clinical colon cancers: advanced tumors express greater levels of DT-diaphorase. | 1998 Sep |
2 |
| 40 |
9865924 | A new screening system for NAD(P)H:quinone oxidoreductase (NQO1)-directed antitumor quinones: identification of a new aziridinylbenzoquinone, RH1, as a NQO1-directed antitumor agent. | 1998 Dec |
2 |
| 41 |
9878310 | The importance of DT-diaphorase in mitomycin C resistance in human colon cancer cell lines. | 1998 Dec |
4 |
| 42 |
9058597 | Involvement of activator protein-1 and nuclear factor-kappaB transcription factors in the control of the DT-diaphorase expression induced by mitomycin C treatment. | 1997 Mar |
8 |
| 43 |
9259406 | Molecular targeting of mitomycin C chemotherapy. | 1997 Aug 7 |
2 |
| 44 |
9406243 | Induction of DT-diaphorase in cancer chemoprevention and chemotherapy. | 1997 |
2 |
| 45 |
8614004 | Reductase enzyme expression across the National Cancer Institute Tumor cell line panel: correlation with sensitivity to mitomycin C and EO9. | 1996 Mar 6 |
2 |
| 46 |
8620484 | Alternative splicing and differential expression of DT-diaphorase transcripts in human colon tumors and in peripheral mononuclear cells in response to mitomycin C treatment. | 1996 Apr 15 |
3 |
| 47 |
8631603 | Biochemical characterization of a mitomycin C-resistant human bladder cancer cell line. | 1996 Mar 15 |
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| 48 |
8665520 | DT-diaphorase as a critical determinant of sensitivity to mitomycin C in human colon and gastric carcinoma cell lines. | 1996 Jun 15 |
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| 49 |
8678904 | Increased DT-diaphorase expression and cross-resistance to mitomycin C in a series of cisplatin-resistant human ovarian cancer cell lines. | 1996 Jul 12 |
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| 50 |
8723519 | Development, pharmacology, role of DT-diaphorase and prospects of the indoloquinone EO9. | 1996 Apr |
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