| 1 |
33974584 | Association Between SHMT1 rs1979277 Polymorphism and Risk of Acute Lymphoblastic Leukemia: A Systematic Review and Meta-analysis. | 2022 Apr 1 |
1 |
| 2 |
32382081 | SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia. | 2021 Feb |
3 |
| 3 |
33521601 | Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate. | 2021 Feb 19 |
1 |
| 4 |
33867731 | Evaluation of LKB1 and Serine-Glycine Metabolism Pathway Genes (SHMT1 and GLDC) Expression in AML. | 2021 Apr |
1 |
| 5 |
34136101 | Modelling of SHMT1 riboregulation predicts dynamic changes of serine and glycine levels across cellular compartments. | 2021 |
3 |
| 6 |
34696588 | Free Energy Landscape and Proton Transfer Pathways of the Transimination Reaction at the Active site of the Serine Hydroxymethyltransferase Enzyme in Aqueous Medium. | 2021 Nov 4 |
4 |
| 7 |
35098008 | Maternal polymorphic loci of rs1979277 serine hydroxymethyl transferase and rs1805087 5-methylenetetrahydrofolate are correlated with the development of fetal growth restriction: A case-control study. | 2021 Dec |
1 |
| 8 |
32142918 | Drosha-independent miR-6778-5p strengthens gastric cancer stem cell stemness via regulation of cytosolic one-carbon folate metabolism. | 2020 May 28 |
1 |
| 9 |
33243973 | Cytosolic serine hydroxymethyltransferase controls lung adenocarcinoma cells migratory ability by modulating AMP kinase activity. | 2020 Nov 26 |
1 |
| 10 |
30522268 | Theoretical Evaluation of the Reaction Mechanism of Serine Hydroxymethyltransferase. | 2019 Jan 17 |
2 |
| 11 |
30787298 | Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction. | 2019 Feb 20 |
3 |
| 12 |
30809670 | The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism. | 2019 May 7 |
3 |
| 13 |
31581160 | High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients. | 2019 Oct 3 |
2 |
| 14 |
29339156 | Structure and function of cytoplasmic serine hydroxymethyltransferase from Pichia pastoris. | 2018 Feb 5 |
1 |
| 15 |
29756317 | Free energy landscapes of prototropic tautomerism in pyridoxal 5'-phosphate schiff bases at the active site of an enzyme in aqueous medium. | 2018 Aug 5 |
1 |
| 16 |
29858389 | Enhancement of 5-Fluorouracil Cytotoxicity by Pyridoxal 5'-Phosphate and Folinic Acid in Tandem. | 2018 Aug |
1 |
| 17 |
29991441 | Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes. | 2018 Sep 1 |
4 |
| 18 |
30035852 | The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells. | 2018 Sep |
1 |
| 19 |
30456347 | Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells. | 2018 May |
2 |
| 20 |
30500180 | Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties. | 2018 Dec 26 |
3 |
| 21 |
28760597 | Human and Plasmodium serine hydroxymethyltransferases differ in rate-limiting steps and pH-dependent substrate inhibition behavior. | 2017 Sep 15 |
2 |
| 22 |
29073064 | Human SHMT inhibitors reveal defective glycine import as a targetable metabolic vulnerability of diffuse large B-cell lymphoma. | 2017 Oct 24 |
1 |
| 23 |
26717037 | A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells. | 2016 Jan 26 |
1 |
| 24 |
25619277 | How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state. | 2015 Apr |
2 |
| 25 |
25677305 | Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase. | 2015 Mar |
2 |
| 26 |
24698160 | Distinct biochemical properties of human serine hydroxymethyltransferase compared with the Plasmodium enzyme: implications for selective inhibition. | 2014 Jun |
1 |
| 27 |
22220685 | Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization. | 2012 Mar |
2 |
| 28 |
21371789 | In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed. | 2011 May |
2 |
| 29 |
19158217 | Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women. | 2009 Mar |
3 |
| 30 |
19244383 | A mathematical model gives insights into the effects of vitamin B-6 deficiency on 1-carbon and glutathione metabolism. | 2009 Apr |
1 |
| 31 |
17482557 | Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells. | 2007 Jun 1 |
2 |
| 32 |
18029478 | Glycine turnover and decarboxylation rate quantified in healthy men and women using primed, constant infusions of [1,2-(13)C2]glycine and [(2)H3]leucine. | 2007 Dec |
4 |
| 33 |
16980404 | Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis. | 2006 Dec |
2 |
| 34 |
17150100 | In silico experimentation with a model of hepatic mitochondrial folate metabolism. | 2006 Dec 6 |
1 |
| 35 |
15170323 | Serine hydroxymethyltransferase: role of glu75 and evidence that serine is cleaved by a retroaldol mechanism. | 2004 Jun 8 |
5 |
| 36 |
12471605 | Structural plasticity of thermophilic serine hydroxymethyltransferases. | 2003 Jan 1 |
2 |
| 37 |
12514178 | Pyridoxal phosphate inhibits dynamic subunit interchange among serine hydroxymethyltransferase tetramers. | 2003 Mar 21 |
1 |
| 38 |
15044825 | Cloning, expression, activity and folding studies of serine hydroxymethyltransferase: a target enzyme for cancer chemotherapy. | 2003 |
2 |
| 39 |
12161434 | Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. | 2002 Oct 11 |
4 |
| 40 |
11386852 | Is mutated serine hydroxymethyltransferase (SHMT) involved in the etiology of neural tube defects? | 2001 Jun |
2 |
| 41 |
11516159 | The role of serine hydroxymethyltransferase isozymes in one-carbon metabolism in MCF-7 cells as determined by (13)C NMR. | 2001 Sep 1 |
1 |
| 42 |
10571879 | Glycine and serine catabolism in non-photosynthetic higher plant cells: their role in C1 metabolism. | 1999 Oct |
2 |
| 43 |
9753690 | The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy. | 1998 Sep 15 |
1 |
| 44 |
11902725 | Alterations in the flow of one-carbon units affect KinB-dependent sporulation in Bacillus subtilis. | 1997 Jul |
1 |
| 45 |
8786078 | Characterisation of a human serine hydroxymethyltransferase pseudogene and its localisation to 1p32.3-33. | 1996 Mar |
2 |
| 46 |
7520695 | Interaction between glycine decarboxylase, serine hydroxymethyltransferase and tetrahydrofolate polyglutamates in pea leaf mitochondria. | 1994 Aug 15 |
1 |
| 47 |
8399818 | A familial/genetic study of plasma serine and glycine concentrations. | 1993 Aug 15 |
2 |
| 48 |
1532227 | Characterization of the formate (for) locus, which encodes the cytosolic serine hydroxymethyltransferase of Neurospora crassa. | 1992 Apr |
1 |
| 49 |
1536856 | Enzymatic mechanism for the hydrolysis of 5,10-methenyltetrahydropteroylglutamate to 5-formyltetrahydropteroylglutamate by serine hydroxymethyltransferase. | 1992 Feb 25 |
1 |
| 50 |
2127307 | Abnormal serine hydroxymethyl transferase activity in the temporal lobes of schizophrenics. | 1990 Dec 11 |
1 |