Ceramides

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protein phosphatase 2 phosphatase activator ; Homo sapiens







42 Article(s)
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1 35159039 GFI1-Dependent Repression of SGPP1 Increases Multiple Myeloma Cell Survival. 2022 Feb 2 1
2 30453012 Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. 2019 Feb 1 1
3 30917007 The NMR-based characterization of the FTY720-SET complex reveals an alternative mechanism for the attenuation of the inhibitory SET-PP2A interaction. 2019 Jun 1
4 29470962 Indomethacin induced glioma apoptosis involving ceramide signals. 2018 Apr 1 1
5 29945972 Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress. 2018 Aug 10 1
6 24676687 Inactivation of protein-phosphatase 2A causing hyperphosphorylation of autoantigenic paraprotein targets in MGUS/MM is due to an exchange of its regulatory subunits. 2014 Nov 1 1
7 25050888 FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels. 2014 2
8 25058613 Characterising the inhibitory actions of ceramide upon insulin signaling in different skeletal muscle cell models: a mechanistic insight. 2014 1
9 23180565 Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis. 2013 Jan 1
10 24025252 Ceramide in the prostate. 2013 Oct 1 5
11 22383528 Neutral sphingomyelinase 2 deficiency increases hyaluronan synthesis by up-regulation of Hyaluronan synthase 2 through decreased ceramide production and activation of Akt. 2012 Apr 20 1
12 22523228 Microcystin-LR induces ceramide to regulate PP2A and destabilize cytoskeleton in HEK293 cells. 2012 Jul 5
13 22652149 Ceramide biosynthesis and metabolism in trophoblast syncytialization. 2012 Oct 15 1
14 22673740 Sorafenib and pemetrexed toxicity in cancer cells is mediated via SRC-ERK signaling. 2012 Jul 3
15 21393425 Modulation of protein phosphatase 2A activity alters androgen-independent growth of prostate cancer cells: therapeutic implications. 2011 May 2
16 21635197 Ceramide formation as a target in beta-cell survival and function. 2011 Sep 1
17 21708940 Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta. 2011 Sep 16 1
18 19698762 Mitochondrial mechanisms in amyloid beta peptide-induced cerebrovascular degeneration. 2010 Mar 1
19 19959757 Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling. 2010 Mar 6
20 20220139 Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis. 2010 Apr 30 2
21 20631069 Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. 2010 Aug 1 1
22 20919648 Ceramide in stress response. 2010 1
23 20954073 Ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells. 2010 9
24 19028839 Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling. 2009 Mar 3
25 19217411 Bad targets the permeability transition pore independent of Bax or Bak to switch between Ca2+-dependent cell survival and death. 2009 Feb 13 1
26 19286927 Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells. 2009 May 5
27 17370039 Autocrine motility-stimulatory pathways of oral premalignant lesion cells. 2007 2
28 17666435 GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. 2007 Aug 15 1
29 16682503 Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis. 2006 Aug 4
30 12492401 Cell-cycle arrest in Jurkat leukaemic cells: a possible role for docosahexaenoic acid. 2003 Apr 15 1
31 12545214 [Protein phosphatase 2A: its structure, function and activity regulation]. 2003 Feb 2
32 12676512 Intracellular signal transduction pathways activated by ceramide and its metabolites. 2003 May 3
33 11801602 De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. 2002 Apr 12 3
34 11897496 Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. 2002 Jun 4
35 11929874 A functional role for the B56 alpha-subunit of protein phosphatase 2A in ceramide-mediated regulation of Bcl2 phosphorylation status and function. 2002 Jun 21 5
36 11480555 Ceramide regulates cellular homeostasis via diverse stress signaling pathways. 2001 Aug 1
37 10793354 Interrelationship between protein phosphatase-2A and cytoskeletal architecture during the endothelial cell response to soluble products produced by human head and neck cancer. 2000 May 1
38 10798219 Effect of beta-sitosterol, a plant sterol, on growth, protein phosphatase 2A, and phospholipase D in LNCaP cells. 2000 1
39 11007961 Type 2A protein phosphatase, the complex regulator of numerous signaling pathways. 2000 Oct 15 1
40 10400650 Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. 1999 Jul 16 6
41 10400653 Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid. 1999 Jul 16 3
42 9605434 Modulation of ceramide-activated protein phosphatase 2A activity by low molecular weight aromatic compounds. 1998 Apr 1 2