PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24676687-6 2014 In lymphoblastoid cell lines from pP-7 carriers, transfection of recombinant B55delta or treatment with ceramide led to a partial reconstitution of PP2A activity and dephosphorylation of pP-7 to wtP7. Ceramides 104-112 protein phosphatase 2 phosphatase activator Homo sapiens 148-152 25058613-6 2014 In contrast, a PP2A-dependent pathway predominantly mediates ceramide-induced inhibition of PKB/Akt in C2C12 myotubes. Ceramides 61-69 protein phosphatase 2 phosphatase activator Homo sapiens 15-19 25050888-7 2014 Structural simulation model had also indicated that the direct binding of ceramide to inhibitor 2 of PP2A (I2PP2A) could reactivate PP2A and cause cell death. Ceramides 74-82 protein phosphatase 2 phosphatase activator Homo sapiens 101-105 25050888-7 2014 Structural simulation model had also indicated that the direct binding of ceramide to inhibitor 2 of PP2A (I2PP2A) could reactivate PP2A and cause cell death. Ceramides 74-82 protein phosphatase 2 phosphatase activator Homo sapiens 109-113 23180565-3 2013 Because I2PP2A/SET was found overexpressed, whereas ceramide was downregulated in lung tumours, a sphingolipid analogue drug, FTY720, was identified to mimick ceramide for binding and targeting I2PP2A/SET, leading to PP2A reactivation, lung cancer cell death, and tumour suppression in vivo. Ceramides 159-167 protein phosphatase 2 phosphatase activator Homo sapiens 10-14 24025252-8 2013 (4) PP2A activity is known to be regulated by the bioactive lipid ceramide, and this occurs through both I2PP2A inhibition and PP2A de-repression and through ceramide actions on subunits of the PP2A enzyme complex. Ceramides 66-74 protein phosphatase 2 phosphatase activator Homo sapiens 4-8 24025252-8 2013 (4) PP2A activity is known to be regulated by the bioactive lipid ceramide, and this occurs through both I2PP2A inhibition and PP2A de-repression and through ceramide actions on subunits of the PP2A enzyme complex. Ceramides 66-74 protein phosphatase 2 phosphatase activator Homo sapiens 107-111 24025252-8 2013 (4) PP2A activity is known to be regulated by the bioactive lipid ceramide, and this occurs through both I2PP2A inhibition and PP2A de-repression and through ceramide actions on subunits of the PP2A enzyme complex. Ceramides 66-74 protein phosphatase 2 phosphatase activator Homo sapiens 107-111 24025252-8 2013 (4) PP2A activity is known to be regulated by the bioactive lipid ceramide, and this occurs through both I2PP2A inhibition and PP2A de-repression and through ceramide actions on subunits of the PP2A enzyme complex. Ceramides 158-166 protein phosphatase 2 phosphatase activator Homo sapiens 4-8 24025252-10 2013 They determined whether ceramide could decrease accumulation of the oncogene c-Myc through inhibition of I2PP2A and activation of PP2A. Ceramides 24-32 protein phosphatase 2 phosphatase activator Homo sapiens 107-111 20220139-8 2010 Finally, activation of DAPK by PP2A was found to be required for ceramide-induced anoikis. Ceramides 65-73 protein phosphatase 2 phosphatase activator Homo sapiens 31-35 22652149-7 2012 Inhibition of the ceramide-responsive JNK and PP2A pathways did not abolish the effects of ceramide, and JNK phosphorylation was unresponsive to ceramide; however, ceramide significantly inhibited phosphorylation of Akt. Ceramides 18-26 protein phosphatase 2 phosphatase activator Homo sapiens 46-50 22673740-7 2012 PP2A can be directly activated by ceramide and SET/I2PP2A can be inhibited by ceramide. Ceramides 34-42 protein phosphatase 2 phosphatase activator Homo sapiens 0-4 22673740-7 2012 PP2A can be directly activated by ceramide and SET/I2PP2A can be inhibited by ceramide. Ceramides 78-86 protein phosphatase 2 phosphatase activator Homo sapiens 0-4 22673740-8 2012 Inhibition of the de novo ceramide synthase pathway blocked drug-induced ceramide generation, PP2A activation and tumor cell killing. Ceramides 26-34 protein phosphatase 2 phosphatase activator Homo sapiens 94-98 22523228-3 2012 Ceramide is an essential second messenger in cells and regulates various cellular mechanisms, including PP2A activation and cytoskeleton destabilization. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 104-108 22523228-7 2012 Furthermore, ceramide may mediate the MCLR-induced upregulation of PP2A activity and protein level of PP2A regulatory subunits in HEK293 cells. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 67-71 22523228-7 2012 Furthermore, ceramide may mediate the MCLR-induced upregulation of PP2A activity and protein level of PP2A regulatory subunits in HEK293 cells. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 102-106 22523228-10 2012 Our results suggest that ceramide may mediate MCLR-induced PP2A regulation and cytoskeleton destabilization. Ceramides 25-33 protein phosphatase 2 phosphatase activator Homo sapiens 59-63 22383528-6 2012 We then showed that in fro/fro fibroblasts, the reduced ceramide was associated with decreased phosphorylation of protein phosphatase 2A (PP2A) and increased phosphorylation of its substrate Akt-p, together with PI3K, PDK1, mTOR (mammalian target of rapamycin), and p70S6K, although PTEN was unaffected. Ceramides 56-64 protein phosphatase 2 phosphatase activator Homo sapiens 138-142 21635197-7 2011 Ceramide-dependent signaling involves activation of extracellularly regulated kinases 1 and 2 (ERK1/2), downregulation of Period (Per)-aryl hydrocarbon receptor nuclear translocator (Arnt)-single-minded (Sim) kinase (PASK), activation of okadaic-acid-sensitive protein phosphatase 2A (PP2A) and stimulation of NADPH-oxidase with generation of superoxides and lipid peroxides. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 285-289 20631069-0 2010 Vorinostat and sorafenib increase CD95 activation in gastrointestinal tumor cells through a Ca(2+)-de novo ceramide-PP2A-reactive oxygen species-dependent signaling pathway. Ceramides 107-115 protein phosphatase 2 phosphatase activator Homo sapiens 116-120 22523228-0 2012 Microcystin-LR induces ceramide to regulate PP2A and destabilize cytoskeleton in HEK293 cells. Ceramides 23-31 protein phosphatase 2 phosphatase activator Homo sapiens 44-48 21708940-7 2011 The mechanisms of PP2A activation by IL-1beta involved neutral sphingomyelinase-2 (NSMase-2) and an accumulation of ceramide. Ceramides 116-124 protein phosphatase 2 phosphatase activator Homo sapiens 18-22 21393425-9 2011 These observations are supported by the effect of ceramide, a PP2A activator, on androgen-independent C4-2 cells. Ceramides 50-58 protein phosphatase 2 phosphatase activator Homo sapiens 62-66 21393425-10 2011 Ceramide inhibited the growth of C4-2 cells on androgen deprivation, an effect that could be abrogated by PP2A downregulation. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 106-110 20220139-0 2010 Protein phosphatase 2A (PP2A) holoenzymes regulate death-associated protein kinase (DAPK) in ceramide-induced anoikis. Ceramides 93-101 protein phosphatase 2 phosphatase activator Homo sapiens 24-28 19698762-4 2010 Ceramide then activates protein phosphatase 2A (PP2A), a member in the ceramide-activated protein phosphatase (CAPP) family. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 48-52 19959757-2 2010 In different cells, two distinct mechanisms have been proposed to mediate ceramide inhibition of PKB/Akt: one involving atypical protein kinase C zeta (PKCzeta) and the other the protein phosphatase-2 (PP2A). Ceramides 74-82 protein phosphatase 2 phosphatase activator Homo sapiens 202-206 19959757-3 2010 We hypothesized that ceramide action through PKCzeta or PP2A might depend on plasma membrane (PM) structural organization and especially on caveolin-enriched domain (CEM) abundance. Ceramides 21-29 protein phosphatase 2 phosphatase activator Homo sapiens 56-60 19959757-4 2010 RESEARCH DESIGN AND METHODS: We have used different PKCzeta mutant constructs or the PP2A inhibitor, okadaic acid (OKA), to selectively inhibit PKCzeta- and PP2A-dependent pathways in cells expressing different caveolin-1 levels and evaluated the impact of insulin and ceramide on PKB/Akt activity in different PM subdomains. Ceramides 269-277 protein phosphatase 2 phosphatase activator Homo sapiens 157-161 19959757-5 2010 RESULTS: Although the PKCzeta-mediated negative effect of ceramide on insulin-stimulated PKB/Akt was dominant in adipocytes, a ceramide action through PP2A outside CEMs, prevented by OKA, was also unraveled. Ceramides 127-135 protein phosphatase 2 phosphatase activator Homo sapiens 151-155 19959757-7 2010 In fibroblasts with low CEM abundance, the ceramide-activated PP2A pathway dominated, but could be shifted to a ceramide-activated PKCzeta pathway after caveolin-1 overexpression. Ceramides 43-51 protein phosphatase 2 phosphatase activator Homo sapiens 62-66 19959757-8 2010 CONCLUSIONS: Our results show that ceramide can switch from a PKCzeta-dependent mechanism to a PP2A pathway, acting negatively on PKB/Akt, and hence revealing a critical role of CEMs of the PM in this process. Ceramides 35-43 protein phosphatase 2 phosphatase activator Homo sapiens 95-99 19286927-0 2009 Ceramide-dependent PP2A regulation of TNFalpha-induced IL-8 production in respiratory epithelial cells. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 19-23 20919648-5 2010 The latter summarizes the mechanisms by which ceramide activate its direct targets, PKCzeta, PP2A and cathepsin D. Ceramides 46-54 protein phosphatase 2 phosphatase activator Homo sapiens 93-97 20954073-4 2010 Treatment of cells with the PP2A inhibitor okadaic acid or with PP2A-Calpha siRNA inhibited ceramide-induced enhanced p27(kip1) protein expression and Akt dephosphorylation, and prevented Skp2 downregulation. Ceramides 92-100 protein phosphatase 2 phosphatase activator Homo sapiens 28-32 20954073-4 2010 Treatment of cells with the PP2A inhibitor okadaic acid or with PP2A-Calpha siRNA inhibited ceramide-induced enhanced p27(kip1) protein expression and Akt dephosphorylation, and prevented Skp2 downregulation. Ceramides 92-100 protein phosphatase 2 phosphatase activator Homo sapiens 64-68 20954073-6 2010 In addition, ceramide stimulated binding of the PP2A catalytic subunit PP2A-Calphabeta to Akt as assessed by immunoprecipitation experiments, indicating that PP2A is involved in the induction of p27(kip1) via inhibition of Akt pathway. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 48-52 20954073-6 2010 In addition, ceramide stimulated binding of the PP2A catalytic subunit PP2A-Calphabeta to Akt as assessed by immunoprecipitation experiments, indicating that PP2A is involved in the induction of p27(kip1) via inhibition of Akt pathway. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 71-75 20954073-6 2010 In addition, ceramide stimulated binding of the PP2A catalytic subunit PP2A-Calphabeta to Akt as assessed by immunoprecipitation experiments, indicating that PP2A is involved in the induction of p27(kip1) via inhibition of Akt pathway. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 71-75 20954073-9 2010 These data reveal that PP2A is a regulator of ceramide-induced p27(kip1) expression via Akt-dependent and Akt-independent pathways. Ceramides 46-54 protein phosphatase 2 phosphatase activator Homo sapiens 23-27 19286927-9 2009 These data suggest that ceramide plays a role in activating PP2A to terminate ongoing IL-8 production. Ceramides 24-32 protein phosphatase 2 phosphatase activator Homo sapiens 60-64 19286927-10 2009 In summary, our data suggest that in respiratory epithelium, TNFalpha induces ceramide accumulation, resulting in subsequent activation of PP2A, which targets those kinases responsible for transcriptional activation of IL-8. Ceramides 78-86 protein phosphatase 2 phosphatase activator Homo sapiens 139-143 20954073-0 2010 Ceramide produces apoptosis through induction of p27(kip1) by protein phosphatase 2A-dependent Akt dephosphorylation in PC-3 prostate cancer cells. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 70-84 20954073-3 2010 Results showed that ceramide increased p27(kip1) protein levels through activation of protein phosphatase 2A (PP2A) in PC-3 prostate cancer cells. Ceramides 20-28 protein phosphatase 2 phosphatase activator Homo sapiens 94-108 20954073-3 2010 Results showed that ceramide increased p27(kip1) protein levels through activation of protein phosphatase 2A (PP2A) in PC-3 prostate cancer cells. Ceramides 20-28 protein phosphatase 2 phosphatase activator Homo sapiens 110-114 19286927-7 2009 Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. Ceramides 99-107 protein phosphatase 2 phosphatase activator Homo sapiens 127-131 19286927-7 2009 Because TNFalpha had been shown to activate ceramide accumulation, and separate studies had linked ceramide with activation of PP2A, we hypothesized the pathway of TNFalpha-inducing ceramide to activate PP2A comprised an endogenous regulatory pathway. Ceramides 99-107 protein phosphatase 2 phosphatase activator Homo sapiens 127-131 17370039-6 2007 The activity of the protein phosphatase PP-2A, which restricts motility and which can be activated by ceramide, was also diminished. Ceramides 102-110 protein phosphatase 2 phosphatase activator Homo sapiens 40-45 19217411-4 2009 Using genetic, biochemical, pharmacological, and functional approaches, we here show that ceramide and staurosporine target PP2A and protein kinases A and C, respectively, in a mitochondria-associated signaling complex to induce dephosphorylation of the BH3-only protein Bad. Ceramides 90-98 protein phosphatase 2 phosphatase activator Homo sapiens 124-128 19028839-4 2009 In addition, studies in A549 human lung cancer cells revealed that ceramide mediates c-Myc degradation via its PP2A-dependent dephosphorylation at S62, and treatment with okadaic acid and expression of c-Myc mutants with S62A or S62D conversions resulted in resistance to ceramide-mediated degradation. Ceramides 67-75 protein phosphatase 2 phosphatase activator Homo sapiens 111-115 19028839-7 2009 Thus, these results suggest that direct interaction of I2PP2A with ceramide plays important biological roles via the regulation of PP2A activity and signaling, which in turn control ceramide-mediated degradation of c-Myc and antiproliferation. Ceramides 67-75 protein phosphatase 2 phosphatase activator Homo sapiens 57-61 19028839-7 2009 Thus, these results suggest that direct interaction of I2PP2A with ceramide plays important biological roles via the regulation of PP2A activity and signaling, which in turn control ceramide-mediated degradation of c-Myc and antiproliferation. Ceramides 182-190 protein phosphatase 2 phosphatase activator Homo sapiens 57-61 17666435-8 2007 These results indicate a role for GSK-3beta in ceramide-induced apoptosis, in which GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 and caspase-8. Ceramides 47-55 protein phosphatase 2 phosphatase activator Homo sapiens 113-117 17370039-8 2007 Treatment with a membrane-permeable ceramide restored PP-2A activity and blocked migration. Ceramides 36-44 protein phosphatase 2 phosphatase activator Homo sapiens 54-59 10400653-2 1999 The search for potential targets for ceramide action led to the identification of ceramide-activated protein phosphatases, which include protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) with roles in regulating apoptosis and cell growth. Ceramides 37-45 protein phosphatase 2 phosphatase activator Homo sapiens 145-159 16682503-0 2006 Lithium inhibits ceramide- and etoposide-induced protein phosphatase 2A methylation, Bcl-2 dephosphorylation, caspase-2 activation, and apoptosis. Ceramides 17-25 protein phosphatase 2 phosphatase activator Homo sapiens 57-71 16682503-3 2006 Here, we report a novel role of lithium on the blockage of ceramide- and etoposide-induced apoptosis via inhibition of protein phosphatase 2A (PP2A) activity. Ceramides 59-67 protein phosphatase 2 phosphatase activator Homo sapiens 127-141 16682503-3 2006 Here, we report a novel role of lithium on the blockage of ceramide- and etoposide-induced apoptosis via inhibition of protein phosphatase 2A (PP2A) activity. Ceramides 59-67 protein phosphatase 2 phosphatase activator Homo sapiens 143-147 16682503-6 2006 Furthermore, ceramide- and etoposide-induced PP2A activation involved methylation of PP2A C subunit, which lithium suppressed. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 45-49 12676512-4 2003 Ceramide also is capable of activating protein phosphatases such as protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 108-122 12676512-4 2003 Ceramide also is capable of activating protein phosphatases such as protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A). Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 124-128 12676512-6 2003 However, the mechanisms how ceramide directly activates enzymes such as JNK and PP2A are still not clear. Ceramides 28-36 protein phosphatase 2 phosphatase activator Homo sapiens 80-84 12545214-6 2003 The second messenger, ceramide, also plays an important role in the regulation of PP2A activity, as well as a plenty of low molecular mass inhibitors of PP2A and other protein phosphatases. Ceramides 22-30 protein phosphatase 2 phosphatase activator Homo sapiens 82-86 12545214-6 2003 The second messenger, ceramide, also plays an important role in the regulation of PP2A activity, as well as a plenty of low molecular mass inhibitors of PP2A and other protein phosphatases. Ceramides 22-30 protein phosphatase 2 phosphatase activator Homo sapiens 153-157 11897496-0 2002 Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A. Ceramides 61-69 protein phosphatase 2 phosphatase activator Homo sapiens 86-100 11897496-4 2002 Since lithium inhibits in vivo the observed protein phosphatase-2A (PP2A) activation induced by ceramide, we hypothesise that the neuroprotective action of lithium may be due to the inhibition of the PP2A activation by apoptotic stimuli. Ceramides 96-104 protein phosphatase 2 phosphatase activator Homo sapiens 52-66 11897496-4 2002 Since lithium inhibits in vivo the observed protein phosphatase-2A (PP2A) activation induced by ceramide, we hypothesise that the neuroprotective action of lithium may be due to the inhibition of the PP2A activation by apoptotic stimuli. Ceramides 96-104 protein phosphatase 2 phosphatase activator Homo sapiens 68-72 11897496-4 2002 Since lithium inhibits in vivo the observed protein phosphatase-2A (PP2A) activation induced by ceramide, we hypothesise that the neuroprotective action of lithium may be due to the inhibition of the PP2A activation by apoptotic stimuli. Ceramides 96-104 protein phosphatase 2 phosphatase activator Homo sapiens 200-204 11480555-12 2001 Ceramide activates protein phosphatases such as protein phosphatase 1 (PP1) and protein phosphatase 2 (PP2A). Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 103-107 10798219-4 2000 PP 2A has been suggested as a direct in vitro target of ceramide action on cell growth and apoptosis. Ceramides 56-64 protein phosphatase 2 phosphatase activator Homo sapiens 0-5 12492401-11 2003 By this pathway, low doses of DHA increase ceramide levels, which leads to inhibition of cdk2 activity and stimulation of PP1 and PP2A. Ceramides 43-51 protein phosphatase 2 phosphatase activator Homo sapiens 130-134 11929874-1 2002 Recently it has been shown that the potent apoptotic agent ceramide activates a mitochondrial protein phosphatase 2A (PP2A) and promotes dephosphorylation of the anti-apoptotic molecule Bcl2 (Ruvolo, P. P., Deng, X., Ito, T., Carr, B. K., and May, W. S. (1999) J. Biol. Ceramides 59-67 protein phosphatase 2 phosphatase activator Homo sapiens 118-122 11929874-4 2002 In cells expressing Bcl2, dephosphorylation of Bcl2 appears to be required for ceramide-induced cell death because treatment of cells with low doses of the PP2A inhibitor okadaic acid blocks Bcl2 dephosphorylation and promotes cell survival. Ceramides 79-87 protein phosphatase 2 phosphatase activator Homo sapiens 156-160 11929874-5 2002 Furthermore, the non-phosphorylatable (i.e. PP2A-resistant) gain-of-function S70E mutant Bcl2 can protect cells from ceramide-induced apoptosis. Ceramides 117-125 protein phosphatase 2 phosphatase activator Homo sapiens 44-48 11929874-10 2002 It is hypothesized that ceramide regulates PP2A via the B-subunit. Ceramides 24-32 protein phosphatase 2 phosphatase activator Homo sapiens 43-47 11929874-11 2002 Thus, understanding the mechanism of how PP2A regulates Bcl2 phosphorylation status and how ceramide might regulate this process requires identification of the regulatory B-subunit of PP2A that comprises the Bcl2 phosphatase. Ceramides 92-100 protein phosphatase 2 phosphatase activator Homo sapiens 184-188 11801602-6 2002 Pretreatment with calyculin A (5 nm), an inhibitor of protein phosphatase-1 (PP1) and protein phosphatase 2A (PP2A) blocked ceramide-induced alternative splicing in contrast to okadaic acid (10 nm), a specific inhibitor of PP2A at this concentrations in cells, demonstrating a PP1-mediated mechanism. Ceramides 124-132 protein phosphatase 2 phosphatase activator Homo sapiens 94-108 11801602-6 2002 Pretreatment with calyculin A (5 nm), an inhibitor of protein phosphatase-1 (PP1) and protein phosphatase 2A (PP2A) blocked ceramide-induced alternative splicing in contrast to okadaic acid (10 nm), a specific inhibitor of PP2A at this concentrations in cells, demonstrating a PP1-mediated mechanism. Ceramides 124-132 protein phosphatase 2 phosphatase activator Homo sapiens 110-114 11801602-6 2002 Pretreatment with calyculin A (5 nm), an inhibitor of protein phosphatase-1 (PP1) and protein phosphatase 2A (PP2A) blocked ceramide-induced alternative splicing in contrast to okadaic acid (10 nm), a specific inhibitor of PP2A at this concentrations in cells, demonstrating a PP1-mediated mechanism. Ceramides 124-132 protein phosphatase 2 phosphatase activator Homo sapiens 223-227 11007961-5 2000 Other molecular mechanisms that regulate PP2Ac function include phosphorylation, carboxyl methylation, inhibition by intracellular protein inhibitors (I(1)(PP2A) and I(2)(PP2A)), and stimulation by ceramide. Ceramides 198-206 protein phosphatase 2 phosphatase activator Homo sapiens 41-45 10793354-8 2000 This was accomplished by use of 1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] and all-trans -retinoic acid to indirectly stimulate PP-2A activity through their capacity to elevated intracellular levels of the second messenger ceramide. Ceramides 230-238 protein phosphatase 2 phosphatase activator Homo sapiens 135-140 10400650-0 1999 Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A. Ceramides 0-8 protein phosphatase 2 phosphatase activator Homo sapiens 80-84 10400650-7 1999 The potent apoptotic agent ceramide can activate a PP2A, suggesting that one potential component of the ceramide-induced death signal may involve the inactivation of Bcl2. Ceramides 27-35 protein phosphatase 2 phosphatase activator Homo sapiens 51-55 10400650-7 1999 The potent apoptotic agent ceramide can activate a PP2A, suggesting that one potential component of the ceramide-induced death signal may involve the inactivation of Bcl2. Ceramides 104-112 protein phosphatase 2 phosphatase activator Homo sapiens 51-55 10400650-8 1999 Results indicate that C2-ceramide but not inactive C2-dihydroceramide, was found to specifically activate a mitochondrial PP2A, which rapidly and completely induced Bcl2 dephosphorylation and correlated closely with ceramide-induced cell death. Ceramides 25-33 protein phosphatase 2 phosphatase activator Homo sapiens 122-126 10400650-10 1999 In contrast, cells overexpressing exogenous wild-type Bcl2 were sensitive to ceramide at dosages where PP2A is fully active and Bcl2 would be expected to be dephosphorylated (IC50 = 14 microM). Ceramides 77-85 protein phosphatase 2 phosphatase activator Homo sapiens 103-107 10400650-11 1999 These findings indicate that in cells expressing functional Bcl2, the mechanism of death action for ceramide may involve, at least in part, a mitochondrial PP2A that dephosphorylates and inactivates Bcl2. Ceramides 100-108 protein phosphatase 2 phosphatase activator Homo sapiens 156-160 10400653-2 1999 The search for potential targets for ceramide action led to the identification of ceramide-activated protein phosphatases, which include protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) with roles in regulating apoptosis and cell growth. Ceramides 37-45 protein phosphatase 2 phosphatase activator Homo sapiens 161-165 10400653-9 1999 These studies disclose stereospecific activation of PP1 and PP2A by long chain natural ceramides under near physiologic ionic strengths in vitro. Ceramides 87-96 protein phosphatase 2 phosphatase activator Homo sapiens 60-64 9605434-2 1998 PP2A is activated by ceramide, which is produced by the hydrolysis of membrane sphingomyelin in response to a variety of stress-related stimuli. Ceramides 21-29 protein phosphatase 2 phosphatase activator Homo sapiens 0-4 9605434-8 1998 Thus, modulation (both inhibition and activation) of the catatylic activity of ceramide-activated PP2A is demonstrated by certain low molecular weight aromatic compounds. Ceramides 79-87 protein phosphatase 2 phosphatase activator Homo sapiens 98-102 30917007-2 2019 Targeting SET with a sphingolipid analog drug fingolimod (FTY720) or ceramide leads to the reactivation of tumor suppressor PP2A. Ceramides 69-77 protein phosphatase 2 phosphatase activator Homo sapiens 124-128 35159039-5 2022 The high S1P:Ceramide intracellular ratio in MM cells protected c-Myc protein stability in a PP2A-dependent manner. Ceramides 13-21 protein phosphatase 2 phosphatase activator Homo sapiens 93-97 30453012-11 2019 A model of how CLN8 along with ceramides affects I2PP2A and PP2A binding and activities is proposed. Ceramides 31-40 protein phosphatase 2 phosphatase activator Homo sapiens 51-55 29945972-8 2018 Conversely, PP2A activation by ceramide or the sphingosine-like compound FTY720 was sufficient to induce TFE3 nuclear translocation. Ceramides 31-39 protein phosphatase 2 phosphatase activator Homo sapiens 12-16 29470962-7 2018 Results suggested that the ceramide/PP2A/Akt axis is involved in the apoptosis and a possible cyclooxygenase-independent target for indomethacin. Ceramides 27-35 protein phosphatase 2 phosphatase activator Homo sapiens 36-40