Cholesterol

cytochrome P450, family 7, subfamily a, polypeptide 1 ; Mus musculus







113 Article(s)
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51 23262749 Diverse effects of oats on cholesterol metabolism in C57BL/6 mice correlate with expression of hepatic bile acid-producing enzymes. 2013 Oct 1
52 23536474 Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. 2013 Sep 4
53 23880190 Inhibition of ileal apical but not basolateral bile acid transport reduces atherosclerosis in apoE⁻/⁻ mice. 2013 Aug 1
54 24255670 Lentinus edodes promotes fat removal in hypercholesterolemic mice. 2013 Dec 1
55 22057115 Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. 2012 Feb 1
56 22098164 Inflammatory stress exacerbates hepatic cholesterol accumulation via disrupting cellular cholesterol export. 2012 May 1
57 22111624 Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases. 2012 May 1
58 22293356 Involvement of interleukin-1 in lead nitrate-induced hypercholesterolemia in mice. 2012 1
59 22607622 Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice. 2012 May 20 2
60 22628034 Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid. 2012 Jul 15 6
61 23139832 Consequences of exchanging carbohydrates for proteins in the cholesterol metabolism of mice fed a high-fat diet. 2012 1
62 21097822 A chronic high-cholesterol diet paradoxically suppresses hepatic CYP7A1 expression in FVB/NJ mice. 2011 Feb 11
63 21319191 Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. 2011 Mar 7
64 21538436 Hepatic organic anion transporting polypeptide transporter and thyroid hormone receptor interplay determines cholesterol and glucose homeostasis. 2011 Aug 1
65 22007308 Mechanism of resistance to dietary cholesterol. 2011 1
66 20623580 Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice. 2010 Aug 2
67 18820241 Loss of small heterodimer partner expression in the liver protects against dyslipidemia. 2009 Feb 2
68 19101514 IL-1 regulates the Cyp7a1 gene and serum total cholesterol level at steady state in mice. 2009 Feb 6 1
69 19721697 REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis. 2009 Sep 1
70 17971517 Clock mutation facilitates accumulation of cholesterol in the liver of mice fed a cholesterol and/or cholic acid diet. 2008 Jan 2
71 18385139 Peroxisome proliferator-activated receptor-gamma coactivator-1alpha activation of CYP7A1 during food restriction and diabetes is still inhibited by small heterodimer partner. 2008 May 30 2
72 18507340 [Hypocholesterolemic effect of stilbene extract from Cajanus cajan L. on serum and hepatic lipid in diet-induced hyperlipidemic mice]. 2008 Feb 1
73 17456796 The cholesterol-raising factor from coffee beans, cafestol, as an agonist ligand for the farnesoid and pregnane X receptors. 2007 Jul 2
74 17654698 Insights in the regulation of cholesterol 7alpha-hydroxylase gene reveal a target for modulating bile acid synthesis. 2007 Sep 1
75 17660447 Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis. 2007 Aug 1
76 17908797 Tissue- and nuclear receptor-specific function of the C-terminal LXXLL motif of coactivator NCoA6/AIB3 in mice. 2007 Dec 2
77 16151615 Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. 2006 Feb 1
78 16260782 Cross-talk between thyroid hormone receptor and liver X receptor regulatory pathways is revealed in a thyroid hormone resistance mouse model. 2006 Jan 6 2
79 16264196 Studies on LXR- and FXR-mediated effects on cholesterol homeostasis in normal and cholic acid-depleted mice. 2006 Feb 2
80 16609145 Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia. 2006 Jul 6
81 16899449 Two uniquely arranged thyroid hormone response elements in the far upstream 5' flanking region confer direct thyroid hormone regulation to the murine cholesterol 7alpha hydroxylase gene. 2006 3
82 17008588 Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol. 2006 Dec 3
83 17142997 Young persimmon fruits prevent the rise in plasma lipids in a diet-induced murine obesity model. 2006 Dec 3
84 17184503 Regulation of hepatic cholesterol metabolism in CETP/LDLr mice by cholesterol feeding and by drugs (cholestyramine and lovastatin) that lower plasma cholesterol. 2006 Dec 1
85 15750181 Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids. 2005 May 6 1
86 16075052 Weaving betaKlotho into bile acid metabolism. 2005 Aug 2
87 16185916 Pituitary control of cholesterol metabolism in normal and LDL receptor knock-out mice: effects of hypophysectomy and growth hormone treatment. 2005 Oct 1 1
88 14762172 Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity. 2004 Feb 17 7
89 14962946 Cholesterol 7alpha-hydroxylase deficiency in mice on an APOE*3-Leiden background impairs very-low-density lipoprotein production. 2004 Apr 2
90 15502389 Pitavastatin, a potent hydroxymethylglutaryl coenzyme a reductase inhibitor, increases cholesterol 7 alpha-hydroxylase gene expression in HepG2 cells. 2004 Nov 1
91 12588950 Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice. 2003 May 1
92 14522988 PGC-1alpha activates CYP7A1 and bile acid biosynthesis. 2003 Dec 12 2
93 11907146 Expression of cholesterol-7alpha-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL. 2002 Apr 6
94 11967256 Dietary cholesterol fails to stimulate the human cholesterol 7alpha-hydroxylase gene (CYP7A1) in transgenic mice. 2002 Jun 7 2
95 12117567 The atypical interaction of peroxisome proliferator-activated receptor alpha with liver X receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha-hydroxylase gene promoter. 2002 Jul 11 2
96 12202481 Mice expressing the human CYP7A1 gene in the mouse CYP7A1 knock-out background lack induction of CYP7A1 expression by cholesterol feeding and have increased hypercholesterolemia when fed a high fat diet. 2002 Nov 8 4
97 12393855 Cholic acid mediates negative feedback regulation of bile acid synthesis in mice. 2002 Oct 1
98 11179691 Regulation of cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription by the liver orphan receptor (LXRalpha). 2001 Jan 10 1
99 11323427 Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7alpha-hydroxylase. 2001 Jun 29 1
100 11397693 2000 George Lyman Duff Memorial Lecture: atherosclerosis is a liver disease of the heart. 2001 Jun 1