N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide

transient receptor potential cation channel subfamily V member 4 ; Homo sapiens







58 Article(s)
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1 34995050 Transient receptor potential vanilloid 4 promotes the growth of non-small cell lung cancer by regulating Foxp3. 2022 Jan 7 7
2 35323756 TRPV4 Stimulation Level Regulates Ca2+-Dependent Control of Human Corneal Endothelial Cell Viability and Survival. 2022 Feb 28 1
3 35366734 Amantadine Attenuated Hypoxia-Induced Mitochondrial Oxidative Neurotoxicity, Apoptosis, and Inflammation via the Inhibition of TRPM2 and TRPV4 Channels. 2022 Jun 1
4 35432302 Emergent Temporal Signaling in Human Trabecular Meshwork Cells: Role of TRPV4-TRPM4 Interactions. 2022 1
5 35469044 NADPH oxidase 4 contributes to TRPV4-mediated endothelium-dependent vasodilation in human arterioles by regulating protein phosphorylation of TRPV4 channels. 2022 Apr 25 1
6 33012175 TRPV4-Mediated Epithelial Junction Disruption in Allergic Rhinitis Triggered by House Dust Mites. 2021 Jul 1
7 33085914 TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous postocclusive reactive and thermal hyperemia. 2021 Apr 1 1
8 33512067 TRPV4 channel activation induces the transition of venous and arterial endothelial cells toward a pro-inflammatory phenotype. 2021 Feb 3
9 33624376 TRPV4 channels mediate the mechanoresponse in retinal microglia. 2021 Jun 1
10 33715198 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid accelerates the healing of colitis by inhibiting transient receptor potential vanilloid 4-mediated signaling. 2021 Apr 1
11 33733088 Activation of TRPV4 channels leads to a consistent tocolytic effect on human myometrial tissues. 2021 Apr 1
12 33788628 TRPV4-Rho signaling drives cytoskeletal and focal adhesion remodeling in trabecular meshwork cells. 2021 Jun 1 1
13 34087722 Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4. 2021 May 25 2
14 34445178 Comparative Analysis of Single-Molecule Dynamics of TRPV1 and TRPV4 Channels in Living Cells. 2021 Aug 6 1
15 34562506 The involvement of TRPV4 on the hypoxia-induced oxidative neurotoxicity and apoptosis in a neuronal cell line: Protective role of melatonin. 2021 Dec 3
16 34673834 TRPV4 is activated by mechanical stimulation to induce prostaglandins release in trabecular meshwork, lowering intraocular pressure. 2021 5
17 34710431 Membrane cholesterol regulates TRPV4 function, cytoskeletal expression, and the cellular response to tension. 2021 1
18 32463112 Mechanisms underlying selective coupling of endothelial Ca2+ signals with eNOS vs. IK/SK channels in systemic and pulmonary arteries. 2020 Sep 3
19 33262985 Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood-Brain Barrier Reveals Interspecies Differences. 2020 2
20 30728775 The TRPV4 Agonist GSK1016790A Regulates the Membrane Expression of TRPV4 Channels. 2019 5
21 30881453 Mechanism for Regulation of Melanoma Cell Death via Activation of Thermo-TRPV4 and TRPV2. 2019 1
22 31064977 The expression and function of TRPV4 channels in primate retinal ganglion cells and bipolar cells. 2019 May 7 1
23 31177523 Endothelial TRPV4 channels modulate vascular tone by Ca2+ -induced Ca2+ release at inositol 1,4,5-trisphosphate receptors. 2019 Sep 1
24 31650038 Differential modulation of transendothelial electrical resistance by TRPV4 agonists is mediated by apoptosis and/or necrosis. 2019 Dec 1
25 29179622 Traumatic Brain Injury Impairs Myogenic Constriction of Cerebral Arteries: Role of Mitochondria-Derived H2O2 and TRPV4-Dependent Activation of BKca Channels. 2018 Apr 1 1
26 29293584 Pharmacological activation of TRPV4 produces immediate cell damage and induction of apoptosis in human melanoma cells and HaCaT keratinocytes. 2018 3
27 29393654 TRPV4 Stimulation Releases ATP via Pannexin Channels in Human Pulmonary Fibroblasts. 2018 Jul 1
28 29791207 Activation of TRPV4 stimulates transepithelial ion flux in a porcine choroid plexus cell line. 2018 Sep 1 1
29 30022772 TRPV4 Channel-Regulated ATP Release Contributes to γ-Irradiation-Induced Production of IL-6 and IL-8 in Epidermal Keratinocytes. 2018 Oct 1 2
30 30328329 Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. 2018 Nov 2
31 27816538 Specific inhibition of TRPV4 enhances retinal ganglion cell survival in adult porcine retinal explants. 2017 Jan 1
32 27869310 TRPV4 Regulates Tight Junctions and Affects Differentiation in a Cell Culture Model of the Corneal Epithelium. 2017 Jul 2
33 28295351 When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor. 2017 Jun 1 2
34 28372987 Disrupting sensitization of TRPV4. 2017 Jun 3 1
35 28655604 Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation. 2017 Sep 1
36 28759041 Oncosis and apoptosis induction by activation of an overexpressed ion channel in breast cancer cells. 2017 Nov 16 1
37 28925524 Hypothermia increases aquaporin 4 (AQP4) plasma membrane abundance in human primary cortical astrocytes via a calcium/transient receptor potential vanilloid 4 (TRPV4)- and calmodulin-mediated mechanism. 2017 Nov 1
38 28945920 Human podocytes express functional thermosensitive TRPV channels. 2017 Dec 1
39 28949006 Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells. 2017 Nov 15 2
40 29100528 Silica nanoparticles inhibit the cation channel TRPV4 in airway epithelial cells. 2017 Nov 3 1
41 26289129 Shear stress mediates exocytosis of functional TRPV4 channels in endothelial cells. 2016 Feb 1
42 27099646 Concurrent shear stress and chemical stimulation of mechano-sensitive cells by discontinuous dielectrophoresis. 2016 Mar 1
43 27616980 Transient Receptor Potential Vanilloid 4 Inhibits γ-Aminobutyric Acid-Activated Current in Hippocampal Pyramidal Neurons. 2016 3
44 27799895 Enhanced Oxidative Stress Is Responsible for TRPV4-Induced Neurotoxicity. 2016 2
45 24906497 Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. 2015 Apr 2
46 24911002 A functional transient receptor potential vanilloid 4 (TRPV4) channel is expressed in human endothelial progenitor cells. 2015 Jan 3
47 25933715 TRPV4 activation triggers the release of melatonin from human non-pigmented ciliary epithelial cells. 2015 Jul 3
48 24034343 TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells. 2014 Feb 5
49 24474754 TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. 2014 Jan 28 1
50 24509911 Modulation of water efflux through functional interaction between TRPV4 and TMEM16A/anoctamin 1. 2014 May 2